The Response of Normal and Ataxia-telangiectasia Human Fibroblasts to the Lethal Effects of Far, Mid and Near Ultraviolet Radiations
| Autor: | D. J. G. Davies, Stephen M. Keyse, S. H. Moss, M.A. McAleer |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Programmed cell death
Strain (chemistry) Cell Survival Ultraviolet Rays Cell Dose-Response Relationship Radiation General Medicine Fibroblasts Biology medicine.disease Molecular biology Cell strain Cell Line Ataxia Telangiectasia medicine.anatomical_structure Cell culture Ataxia-telangiectasia Immunology medicine Humans Near ultraviolet Fibroblast |
| Zdroj: | International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine. 48:975-985 |
| ISSN: | 0020-7616 |
| DOI: | 10.1080/09553008514552101 |
| Popis: | The responses of two ataxia-telangiectasia (A-T) cell strains to the lethal effects of monochromatic far, mid and near ultraviolet radiations have been determined and compared with the responses of three normal human cell strains. Our results confirm a previous observation that the A-T cell strain AT4BI is abnormally sensitive to the lethal effects of mid u.v. (313 nm) radiation. After far u.v. (254 nm) radiation the strain AT4BI exhibits a small but statistically significant increase in sensitivity compared to the normal strains. Of most interest, in terms of a mechanistic interpretation of the sensitivity of A-T strains, the survival responses of neither A-T strain tested to near u.v. (365 nm) radiation differed significantly from the mean response of the normal strains, although it is of interest that one normal strain (48BR) was found to be significantly more resistant to near u.v. radiation than any of the other strains tested. The results are discussed in terms of the possible induction of radiogenic lesions in DNA by ultraviolet radiations and the possible mechanisms of radiation sensitivity in ataxia-telangiectasia. |
| Databáze: | OpenAIRE |
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