Immunohistochemical demonstration of RECK protein and interleukin-6 in fetal membranes from singleton pregnancies with late preterm delivery, intact membranes and histological chorioamnionitis
| Autor: | Zdeslav Benzon, Vedran Stefanovic, Ivana Kuzmić Prusac, Sandra Benzon, Sandra Zekic Tomas, Marko Vulić, Luka Vulić |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
0301 basic medicine Histology chorioamnionitis IL-6 placental membranes PPROM Chorioamnionitis fetal membranes human pregnancy preterm delivery Extraembryonic Membranes Gestational Age Inflammation GPI-Linked Proteins Andrology 03 medical and health sciences 0302 clinical medicine Pregnancy medicine Humans 10. No inequality Interleukin 6 Fetus 030219 obstetrics & reproductive medicine biology Interleukin-6 business.industry Gestational age General Medicine Reference Standards medicine.disease Immunohistochemistry 3. Good health Medical Laboratory Technology 030104 developmental biology Membrane biology.protein Female medicine.symptom business |
| Zdroj: | Biotechnic & Histochemistry. 93:575-580 |
| ISSN: | 1473-7760 1052-0295 |
| DOI: | 10.1080/10520295.2018.1511061 |
| Popis: | We investigated whether chorioamnionitis affects immunohistochemical demonstration of RECK protein and interleukin-6 (IL-6) expression in fetal placental membranes following late preterm delivery with intact membranes. Fetal membranes of 28 women with single pregnancy, preterm delivery and histologically documented chorioamnionitis at gestational age 34−366/7 weeks constituted the chorioamnionitis study group. The control group consisted of 28 fetal membranes from women with preterm deliveries at the same gestational age without histological chorioamnionitis. Immunohistochemistry was performed using monoclonal antibodies against RECK protein and IL-6. We found a statistically significant difference in RECK expression between the chorioamnionitis and control groups ; however, we found no difference in IL-6 expression between the groups. We demonstrated that RECK expression is down-regulated in fetal membranes from pregnancies with spontaneous late preterm birth and intact membranes, which suggests its role in preterm parturition. Equal expression of IL-6 in fetal membranes of pregnancies with and without histological chorioamnionitis is an intriguing and unexpected observation that requires further investigation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |