Interindividual variability in the cholesterol-lowering effect of supplementation with plant sterols or stanols
| Autor: | J.M. Bard, Jean-Michel Lecerf, Frédéric Fumeron |
|---|---|
| Přispěvatelé: | Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Mer, molécules et santé EA 2160 (MMS), Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques, Université de Nantes (UN)-Université de Nantes (UN)-Le Mans Université (UM)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN), FR 3473 Institut universitaire Mer et Littoral (IUML), Le Mans Université (UM)-Université d'Angers (UA)-Université de Nantes (UN)-École Centrale de Nantes (ECN)-Université de Bretagne Sud (UBS)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Nutrition Humaine (CRNH), Centre hospitalier universitaire de Nantes (CHU Nantes), Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER, Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP), École pratique des hautes études (EPHE)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Le Mans Université (UM)-Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques, Université de Bretagne Sud (UBS)-Le Mans Université (UM)-Université d'Angers (UA)-Centre National de la Recherche Scientifique (CNRS)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Nantes (UN)-École Centrale de Nantes (ECN), Centre René Gauducheau - ICO, institut de Cancerologie de l'Ouest, Le Mans Université (UM)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques, Fumeron, Frédéric |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
MESH: Anticholesteremic Agents/administration & dosage [SDV]Life Sciences [q-bio] MESH: Plant Oils/chemistry Medicine (miscellaneous) MESH: Dietary Supplements MESH: Lipoproteins/genetics MESH: Membrane Proteins/blood MESH: Vegetables/chemistry plant sterols Intestinal absorption chemistry.chemical_compound Vegetables cholesterol transporters Nuts LDL-cholesterol genetics Food science ATP Binding Cassette Transporter Subfamily G Member 5 MESH: Lipoproteins/blood Randomized Controlled Trials as Topic MESH: Phytosterols/administration & dosage Nutrition and Dietetics Anticholesteremic Agents intestinal absorption Phytosterols [SDV] Life Sciences [q-bio] Cholesterol MESH: Apolipoproteins E/genetics Biochemistry MESH: ATP Binding Cassette Transporter Subfamily G Member 5/blood lipids (amino acids peptides and proteins) MESH: ATP Binding Cassette Transporter Subfamily G Member 8/blood MESH: Cholesterol/blood Cholesterol synthesis MESH: ATP Binding Cassette Transporter Subfamily G Member 5/genetics MESH: ATP Binding Cassette Transporter Subfamily G Member 8/genetics Lipoproteins MESH: Fruit/chemistry Biology MESH: Membrane Proteins/genetics 03 medical and health sciences Apolipoproteins E Meta-Analysis as Topic MESH: Diet MESH: Polymorphism Genetic Humans Plant Oils MESH: Meta-Analysis as Topic Dietary supplementation MESH: Apolipoproteins E/blood MESH: Sitosterols/administration & dosage Cholesterol absorption Polymorphism Genetic MESH: Humans 030109 nutrition & dietetics MESH: Nuts/chemistry ATP Binding Cassette Transporter Subfamily G Member 8 Membrane Proteins Membrane Transport Proteins Cholesterol lowering MESH: Edible Grain/chemistry Sitosterols Diet [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition MESH: Randomized Controlled Trials as Topic chemistry Plant stanol ester Fruit Dietary Supplements Edible Grain individual response [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition Plant sterols |
| Zdroj: | Nutrition Reviews Nutrition Reviews, Oxford University Press (OUP), 2017, 75 (2), pp.134-145. ⟨10.1093/nutrit/nuw059⟩ Nutrition Reviews, 2017, 75 (2), pp.134-145. ⟨10.1093/nutrit/nuw059⟩ |
| ISSN: | 1753-4887 0029-6643 |
| DOI: | 10.1093/nutrit/nuw059 |
| Popis: | International audience; Low-density lipoprotein cholesterol (LDL-C) plays a causal role in atherosclerosis. One way to reduce LDL-C levels is to inhibit cholesterol absorption. Plant sterols and stanols compete with cholesterol for absorption in the intestine and induce an average decrease in LDL-C by 5% to 15% in a dose-dependent manner, but not in all individuals. This review focuses on the interindividual variability in response to dietary supplementation with plant sterols and stanols. Dietary plant sterols and stanols have no significant effects on LDL-C in substantial numbers of individuals. Higher responses, in absolute value and percentage of LDL-C, are observed in individuals with higher cholesterol absorption and a lower rate of cholesterol synthesis. Some data provide evidence of the influence of genetics on the response to plant sterols and stanols. Further studies in large populations are required to extend these conclusions about genetic influences. |
| Databáze: | OpenAIRE |
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