Spatio-temporal dynamics of interictal activity in musicogenic epilepsy: Two case reports and a systematic review of the literature
| Autor: | Laura Mirandola, Pietro Avanzini, Giada Giovannini, Stefano Meletti, Giovanni Vecchiato, Arturo Nuara, Carlo Alberto Tassinari, Anna Elisabetta Vaudano, Maddalena Fabbri-Destro |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
050105 experimental psychology Epilepsy Reflex 03 medical and health sciences Seizure onset 0302 clinical medicine Reflex Epilepsy Seizures Physiology (medical) Music Music processing Musicogenic seizure Musicolepsia Reflex epilepsies Medicine Humans 0501 psychology and cognitive sciences Ictal business.industry 05 social sciences Brain Musicogenic epilepsy Electroencephalography Neurophysiology Middle Aged Sensory Systems Neurology Musical stimulus Frontal lobe Female Neurology (clinical) business Neuroscience 030217 neurology & neurosurgery |
| Popis: | Objective To explore neurophysiological features of musicogenic epilepsy (ME), discussing experimental findings in the framework of a systematic review on ME. Methods Two patients with ME underwent high-density-electroencephalography (hd-EEG) while listening to ictogenic songs. In one case, musicogenic seizures were elicited. Independent component analysis (ICA) was applied to hd-EEG, and components hosting interictal and ictal elements were identified and localized. Finally, the temporal dynamics of spike-density was studied relative to seizures. All findings were compared against the results of a systematic review on ME, collecting 131 cases. Results Interictal spikes appeared isolated in specific fronto-temporal independent components, whose cortical generators were located in the anterior temporal and inferior frontal lobe. In the patient undergoing seizure, ictal discharge relied in the same component, with the interictal spike-density decreasing before the seizure onset. Conclusion Our study shows how ICA can isolate neurophysiological features of ictal and interictal discharges in ME, highlighting a fronto-temporal localization and a suppression of spike-density preceding the seizure onset. Significance While the localization of ME activity could indicate which aspect within the musical stimulus might trigger musicogenic seizures for each patient, the study of ME dynamics could contribute to the development of models for seizure-prediction and their validation. |
| Databáze: | OpenAIRE |
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