Early high amino-acid intake is associated with hypophosphatemia in preterm infants

Autor: Maria Fernanda Galletti, Pablo Hernan Brener Dik, Silvia Anahi Fernandez Jonusas, Debora Sabatelli, Carla Chiesa, Silvana Perez, Mariana Brusadin, Larissa Genes, Isabel Araya, Gonzalo Luis Mariani
Rok vydání: 2021
Předmět:
Zdroj: Journal of perinatology : official journal of the California Perinatal Association. 42(8)
ISSN: 1476-5543
Popis: To estimate the incidence of hypophosphatemia in preterm infants according to parenteral nutrition received and to evaluate associated risk factors.A prospective multicenter cohort study included 111 patients ≤ 1250 g (7 NICUs of the NEOCOSUR Network). Two groups were compared according to the amino-acid supply in the first 48 h: aggressive parenteral group ≥ 3 g/kg/day and standard parenteral group:2.9 g/kg/day. Hypophosphatemia was defined as serum phosphate4 mg/dl. A logistic regression analysis was performed to evaluate associated risk factors.Fifty-eight infants received aggressive parenteral nutrition. The incidence of hypophosphatemia was significantly higher in the aggressive parenteral group (77.5% vs 53.8%, p = 0.009). Hypophosphatemia was independently associated with aggressive parenteral nutrition (aOR 4.16 95% CI 1.54-12.24) and negatively associated with phosphorous intake (aOR 0.92 95% CI 0.87-0.97).Both high amino-acid intake and low phosphorus supply during the first days after birth were independently associated with hypophosphatemia.
Databáze: OpenAIRE
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