Branched chain amino acid transaminase 1 (BCAT1) is overexpressed and hypomethylated in patients with non-alcoholic fatty liver disease who experience adverse clinical events: A pilot study
| Autor: | Anna Mae Diehl, Kara Wegermann, Cynthia A. Moylan, Susan K. Murphy, Manal F. Abdelmalek, Ricardo Henao |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cirrhosis Biopsy lcsh:Medicine Gene Expression Branched chain amino acid transaminase 1 Gastroenterology Biochemistry 0302 clinical medicine Medicine and Health Sciences lcsh:Science Hepatic encephalopathy Regulation of gene expression Multidisciplinary DNA methylation medicine.diagnostic_test Liver Diseases Fatty liver Chromatin 3. Good health Nucleic acids Liver biopsy 030211 gastroenterology & hepatology Epigenetics DNA modification Chromatin modification Research Article Chromosome biology medicine.medical_specialty Cell biology Surgical and Invasive Medical Procedures Gastroenterology and Hepatology 03 medical and health sciences Internal medicine medicine Genetics Decompensation Treatment Guidelines Health Care Policy Biology and life sciences business.industry lcsh:R DNA medicine.disease Fibrosis Fatty Liver Health Care 030104 developmental biology lcsh:Q business Developmental Biology |
| Zdroj: | PLoS ONE PLoS ONE, Vol 13, Iss 9, p e0204308 (2018) |
| ISSN: | 1932-6203 |
| Popis: | Background and objectives Although the burden of non-alcoholic fatty liver disease (NAFLD) continues to increase worldwide, genetic factors predicting progression to cirrhosis and decompensation in NAFLD remain poorly understood. We sought to determine whether gene expression profiling was associated with clinical decompensation and death in patients with NAFLD, and to assess whether altered DNA methylation contributes to these changes in gene expression. Methods We performed a retrospective analysis of 86 patients in the Duke NAFLD Clinical Database and Biorepository with biopsy-proven NAFLD whose liver tissue was previously evaluated for gene expression and DNA methylation using array based technologies. We assessed the prospective development of liver and cardiovascular disease related outcomes, including hepatic decompensation as identified by the development of ascites, hepatic encephalopathy, hepatocellular carcinoma, or variceal bleeding as well as stroke and myocardial infarction via medical chart review. Results Of the 86 patients, 47 had F0-F1 fibrosis and 39 had F3-F4 fibrosis at index liver biopsy. Gene expression probe sets (n = 54,675) were analyzed; 42 genes showed significant differential expression (p |
| Databáze: | OpenAIRE |
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