Sevoflurane- and propofol-based regimens show comparable effect on oxygenation in patients undergoing cardiac valve replacement with cardiopulmonary bypass
| Autor: | Xiaozhen Wei, Zhen Luo, Guizhi Du, Yunxia Zuo |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male China Time Factors Lung injury Sevoflurane law.invention law Fraction of inspired oxygen Cardiopulmonary bypass Humans Medicine Prospective Studies Lung Propofol Heart Valve Prosthesis Implantation Cardiopulmonary Bypass Inhalation business.industry Hemodynamics Lung Injury General Medicine Oxygenation Middle Aged Heart Valves Oxygen Regimen Treatment Outcome Anesthesia Anesthetics Inhalation Respiratory Mechanics Female Cardiology and Cardiovascular Medicine business Anesthetics Intravenous circulatory and respiratory physiology medicine.drug |
| Zdroj: | Cardiovascular Journal of Africa. 31:19-22 |
| ISSN: | 1680-0745 1995-1892 |
| DOI: | 10.5830/cvja-2019-050 |
| Popis: | Background Our study aimed to compare the effects of Sevoflurane- and propofol-based anaesthetic regimens on oxygenation during the early period of cardiopulmonary bypass (CPB) in patients undergoing cardiac valve-replacement surgery. Methods Patients undergoing mechanical mitral, aortic or double valve replacement were enrolled and randomly divided into two groups: the sevoflurane-based anaesthetic regimen group consisted of patients who received 1-3% sevoflurane inhalation during anaesthesia maintenance and the propofol-based anaesthetic regimen group consisted of patients who received 6-10 mg/kg/h of propofol infusion during anaesthesia maintenance. The partial pressure of oxygen/fraction of inspired oxygen (PaO2/FiO2), respiratory mechanics and haemodynamics were recorded during CPB. Results Forty-two patients met the eligibility criteria for the study. The groups did not differ in terms of clinical and demographic characteristics, and pre- and intra-operative features. Changes in oxygenation were mild (mean PaO2/FiO2 from 358 ± 82 to 471 ± 106 mmHg) within one hour of CPB in our patients. There were no differences in PaO2/FiO2, respiratory mechanics and haemodynamics between the sevoflurane and propofol groups. Conclusions In patients undergoing cardiac valve replacement with CPB, lung injury was mild, and sevoflurane- and propofol-based anaesthetic regimens showed similar effect on oxygenation, respiratory mechanics and haemodynamics during the early stage of CPB. |
| Databáze: | OpenAIRE |
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