Resistance Training Does not have an Effect on Cognition or Related Serum Biomarkers in Nonagenarians: A Randomized Controlled Trial
| Autor: | Gabriel Rodríguez-Romo, Jonatan R. Ruiz, Francisco-Javier Gil-Bea, Natalia Bustamante-Ara, José Antonio Serra-Rexach, Alejandro Lucia, Angel Cedazo-Minguez, Carmen Fiuza-Luces |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Ciencia Aging medicine.medical_specialty Envejecimiento Cognitive decline Salud Physical Therapy Sports Therapy and Rehabilitation Peptidyl-Dipeptidase A law.invention Amyloid beta-Protein Precursor Cognition Elderly Randomized controlled trial law Humans Medicine Orthopedics and Sports Medicine Muscle Strength Mini-mental state examination Leg press Aged 80 and over Mini–Mental State Examination Epidermal Growth Factor biology medicine.diagnostic_test Tumor Necrosis Factor-alpha Physical activity business.industry Brain-Derived Neurotrophic Factor Resistance Training Angiotensin-converting enzyme Blood Proteins Ejercicio físico Blood proteins biology.protein Physical therapy Female Geriatric Depression Scale Cognitive function business Biomarkers |
| Zdroj: | International Journal of Sports Medicine. 36:54-60 |
| ISSN: | 1439-3964 0172-4622 |
| DOI: | 10.1055/s-0034-1375693 |
| Popis: | The aim of this randomized controlled trial was to determine the effects of 8-week exercise-intervention on cognition and related serum biochemical markers in nonagenarians. We also studied the effects of a 4-week training cessation (‘detraining’) period on our study variables. Participants were randomly allocated to a standard-care (control) or intervention (exercise) group [n=20 (16 women)/group]. The intervention focused on supervised, light-to-moderate-intensity aerobic and resistance exercises (mainly leg press), and included 3 weekly sessions. Cognitive status was determined by the mini-mental state examination and geriatric depression scale. We analysed proteins with reported relation with mechanisms behind cognition changes such as serum levels of angiotensin converting enzyme, amyloid-precursor protein, epidermal growth factor, brain-derived neural factor and tumor necrosis factor. No significant change (P>0.05) in any of the variables studied was found following the exercise intervention compared with the standard-care group. Similarly, no significant changes (P>0.05) were observed following the detraining period compared with the standard-care group. Overall changes after the exercise intervention in serum biomarkers were not associated with changes in functional capacity and cognitive measures. An 8-week exercise intervention focusing on resistance exercises neither benefits cognitive function nor affects the levels of the serum proteins analysed in nonagenarians. |
| Databáze: | OpenAIRE |
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