Haemorrhage rates of ruptured and unruptured brain arteriovenous malformation after radiosurgery: a nationwide population-based cohort study
| Autor: | Kuo-Wei Wang, Shyh-An Yeh, Cheng-Loong Liang, Cien-Leong Chye, James Taoqian Tang, Han-Jung Chen |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Intracranial Arteriovenous Malformations Male medicine.medical_specialty Pediatrics medicine.medical_treatment Population Taiwan Hemorrhage Radiosurgery Cohort Studies 03 medical and health sciences 0302 clinical medicine medicine Humans neurosurgery 030212 general & internal medicine education Stroke Survival analysis Retrospective Studies education.field_of_study business.industry Brain Arteriovenous malformation Retrospective cohort study General Medicine medicine.disease stroke Treatment Outcome Neurology stroke medicine Medicine Neurosurgery business 030217 neurology & neurosurgery Follow-Up Studies Cohort study |
| Zdroj: | BMJ Open, Vol 10, Iss 10 (2020) BMJ Open |
| ISSN: | 2044-6055 |
| Popis: | ObjectivesThe present nationwide population-based cohort study aims to assess the effectiveness of gamma knife radiosurgery (GKS) on ruptured and unruptured brain arteriovenous malformations (AVMs) by evaluating the haemorrhage rates.DesignA nationwide, retrospective cohort study.SettingTaiwan National Health Insurance Research Database (NHIRD).ParticipantsAn observational study of 1515 patients who were diagnosed with brain AVMs between 1997 and 2013 from the Taiwan NHIRD.Primary outcome and secondary outcome measuresWe performed a survival analysis using the Kaplan-Meier method. Multivariate Cox proportional hazards regression models were used to explore the relationship between treatment modalities (GKS vs non-GKS) and haemorrhage, adjusted for age and sex.ResultsThe GKS and non-GKS groups included 317 and 1198 patients, respectively. Patients in the GKS group (mean±SD, 33.08±15.48 years of age) tended to be younger than those in the non-GKS group (37.40±17.62) (p40 years of age (aHR 3.21; 95% CI 1.12 to 9.14).ConclusionsGKS is safe and it reduces the risk of haemorrhage in patients with ruptured AVMs. The administration of GKS to patients with unruptured AVMs who are above the age of 40 years old male might increase the risk of haemorrhage. |
| Databáze: | OpenAIRE |
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