Genetic susceptibility of Henoch-Schönlein purpura in children
| Autor: | Jasmine Naru, Neha Nanda, Manila Salaria, Ritu Aggarwal, Deepti Suri, Surjit Singh, Anju Gupta |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Biochemistry
medical Henoch-Schonlein purpura biology business.industry Biochemistry (medical) Bioinformatics medicine.disease Major histocompatibility complex Molecular medicine Biochemistry Human genetics Pathogenesis Purpura Poster Presentation Genetic predisposition Etiology biology.protein Genetics Medicine Molecular Medicine Genetics(clinical) medicine.symptom business Molecular Biology Genetics (clinical) |
| Zdroj: | Molecular Cytogenetics |
| ISSN: | 1755-8166 |
| DOI: | 10.1186/1755-8166-7-s1-p65 |
| Popis: | Background Henoch-Schonlein purpura (HSP) is a small vessel vasculitis typically observed in children, 3-10 years old. The aetiology is unclear. Interaction of several environmental factors, including infections and multiple genes has been proposed to play a role in pathogenesis. An increased familial occurrence is an indicator of genetic predisposition; association with a major histocompatibility complex is plausible. The aim of the study was to investigate the association of HLA-DRB1 (HLA class II antigen) with HSP. |
| Databáze: | OpenAIRE |
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