FDG-PET probe-guided surgery for recurrent retroperitoneal testicular tumor recurrences
| Autor: | J. S. de Jong, Harald J. Hoekstra, Nanno Mulder, Anne M. J. Paans, Riemer H. J. A. Slart, van Robert Ginkel, Clara Lemstra |
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| Přispěvatelé: | Vascular Ageing Programme (VAP), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Cardiovascular Centre (CVC), Translational Immunology Groningen (TRIGR) |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Non-seminoma Dysgerminoma Testis cancer Lesion POSITRON-EMISSION-TOMOGRAPHY Testicular Neoplasms Surgical oncology Fluorodeoxyglucose F18 Predictive Value of Tests medicine Retroperitoneal space Humans Retroperitoneal Neoplasms Testicular cancer Tumor marker Handheld PET probe HELD GAMMA-PROBE medicine.diagnostic_test business.industry LOCALIZATION General Medicine Retroperitoneal medicine.disease CANCER Surgery GERM-CELL TUMOR medicine.anatomical_structure PET Oncology Positron emission tomography Gamma Rays Predictive value of tests Positron-Emission Tomography Radiology medicine.symptom Radiopharmaceuticals business Tomography X-Ray Computed Gamma probe |
| Zdroj: | European Journal of Surgical Oncology, 36(11), 1092-1095. ELSEVIER SCI LTD |
| ISSN: | 1532-2157 0748-7983 |
| Popis: | Aim: Tumor marker based recurrences of previously treated testicular cancer are generally detected with CT scan. They sometimes cannot be visualized with conventional morphologic imaging. FDG-PET has the ability to detect these recurrences. PET probe-guided surgery, may facilitate the extent of surgery and optimize the surgical resection.Methods: Three patients with resectable 2nd or 3rd recurrent testicular cancer based on elevated tumor markers after previous various chemotherapy schedules and resections of residual retroperitoneal tumor masses were included in this study. A diagnostic FDG-PET was performed and a hotspot in previously operated area of the retroperitoneal space in all three patients was visualized. PET probe-guided surgery was performed using a high-energy gamma probe 3 h post-injection of 500 MBq FDG.Results: All patients showed extended adhesions and scar tissue in the retroperitoneal area due to the previous surgeries. Pre-operative PET/CT scan showed a good correlation with intra-operative PET probe-guided detection of recurrent lesions. There was a high target to background ratio (TGB) of 5:1 during the procedure. In one patient, a 2 cm large lesion, which did not show on pre-operative FDG-PET scan, was detected with the PET probe. Histopathologic tissue evaluation demonstrated recurrent vital tumor in all PET probe positive lesions.Conclusions: PET probe-guided surgery seems to be a promising tool to localize FDG-PET positive lesion in recurrent testicular cancer in hardly accessible surgical locations. PET probe-guided surgery might be a useful technique in surgical oncology for recurrent testicular cancer and has the potential to be applied in surgery of other malignant diseases. (C) 2010 Elsevier Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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