Improvement of Chemical and Physical Properties and Antioxidant Evaluation of Eugenol - PEG adduct
| Autor: | Marina Zacchigna, Giuseppe Procida, Francesca Cateni |
|---|---|
| Přispěvatelé: | Zacchigna, Marina, Cateni, Francesca, Procida, Giuseppe |
| Rok vydání: | 2018 |
| Předmět: |
Antioxidant
medicine.medical_treatment Kinetics 02 engineering and technology Plant Science 01 natural sciences Antioxidants Adduct Polyethylene Glycols chemistry.chemical_compound Plasma Antioxidant activity Picrates Drug Discovery PEG ratio Eugenol PEG Drug delivery medicine Humans Pharmacology 010405 organic chemistry Biphenyl Compounds General Medicine Buffer solution Prodrug 021001 nanoscience & nanotechnology 0104 chemical sciences Complementary and alternative medicine chemistry 0210 nano-technology Nuclear chemistry |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1934-578X |
| Popis: | Eugenol (EU) – PEG adduct was synthesized to improve the chemical and physical properties of eugenol. The phenolic group was covalently bound to the carboxyl group of PEG and the release kinetics were studied in vitro in buffer solution at pH 7.4, in simulated gastric fluid and in mouse plasma. Studies in vitro on the release of the parent drug from the prodrug in various media indicate that the adduct may be sufficiently stable to pass intact into the gastrointestinal tract and release EU into the circulation. The antioxidant activity of PEG-EU adduct was also evaluated. Scavenging activity was absent in the original PEG-EU adduct but gradually increased on the basis of drug delivery. |
| Databáze: | OpenAIRE |
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