Spectrum of cardiac abnormalities associated with long QT in stroke survivors
| Autor: | Allan D. Struthers, K Y K Wong, Stephen Mcswiggan, N Kennedy, Ronald S. MacWalter, Suzanne Y.S. Wong, A. Gavin |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty education Diastole Myocardial Ischemia Blood Pressure Cardiovascular Medicine QT interval Electrocardiography Ventricular Dysfunction Left Internal medicine Heart rate Medicine Heart rate variability Humans Single-Blind Method cardiovascular diseases Prospective Studies Stroke Aged Aged 80 and over business.industry Vascular disease fungi food and beverages Middle Aged medicine.disease humanities Long QT Syndrome Blood pressure Circulatory system Cardiology cardiovascular system Electrocardiography Ambulatory Female Hypertrophy Left Ventricular Cardiology and Cardiovascular Medicine business Cardiomyopathies |
| Zdroj: | Heart (British Cardiac Society). 91(10) |
| ISSN: | 1468-201X |
| Popis: | Objectives: To find out what spectrum of cardiac abnormalities are found in those stroke survivors who can be deemed to be at high cardiac risk by their having long QT. Methods: 202 patients with good recovery from a cerebrovascular event occurring at least one month previously were recruited into a prospective epidemiological study. These stroke survivors underwent a battery of cardiac investigations including 12 lead ECG, echocardiography, myocardial perfusion scanning, and heart rate variability assessment. The ECGs were digitised by a single observer blinded to the blood pressure and other investigations of the patients. The maximum heart rate corrected QT interval (QTc max) in the 12 lead ECG was derived by Bazett’s formula. Results: Prolonged QTc max significantly correlated with increasing blood pressure, left ventricular mass index, and depressed heart rate variability. As the number of cardiac abnormalities increased, QTc max became more prolonged. Conclusions: Long QT is significantly associated with left ventricular mass index even after adjustment for both systolic and diastolic blood pressures. Long QT was also associated with the total cardiac disease burden. These two observations may explain why stroke survivors with long QTc max were at greater risk of cardiac death. |
| Databáze: | OpenAIRE |
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