Correlation and Agreement of Yttrium-90 Positron Emission Tomography/Computed Tomography with Ex Vivo Radioembolization Microsphere Deposition in the Rabbit VX2 Liver Tumor Model
| Autor: | Andrew C. Gordon, Andrew C. Larson, Samdeep K. Mouli, Reed A. Omary, Kent T. Sato, Robert J. Lewandowski, Kathleen R. Harris, Robert K. Ryu, Riad Salem, Vanessa L. Gates, Weiguo Li, Zhuoli Zhang, Sarah B. White, Donald Samaan, J. Nicolai, Daniel Procissi |
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| Rok vydání: | 2021 |
| Předmět: |
Liver tumor
chemistry.chemical_element Radiation Dosage Article 030218 nuclear medicine & medical imaging Microsphere Necrosis 03 medical and health sciences Liver Neoplasms Experimental 0302 clinical medicine Predictive Value of Tests Positron Emission Tomography Computed Tomography medicine Animals Yttrium Radioisotopes Radiology Nuclear Medicine and imaging Positron Emission Tomography-Computed Tomography medicine.diagnostic_test business.industry Magnetic resonance imaging Yttrium medicine.disease Embolization Therapeutic Tumor Burden chemistry Positron emission tomography 030220 oncology & carcinogenesis Radiographic Image Interpretation Computer-Assisted Female Rabbits Radiopharmaceuticals Cardiology and Cardiovascular Medicine Nuclear medicine business Correction for attenuation Ex vivo |
| Zdroj: | J Vasc Interv Radiol |
| ISSN: | 1051-0443 |
| Popis: | PURPOSE: To demonstrate stronger correlation and agreement of (90)Y PET/CT measurements with explant liver tumor dosing compared to the Standard Model (SM) for radioembolization. MATERIALS AND METHODS: Hepatic VX2 tumors were implanted into New Zealand White rabbits with growth confirmed on 7T MRI. Seventeen VX2 rabbits provided 33 analyzed tumors. Treatment volumes were calculated with manually drawn volumes of interest (VOI) with 3D surface renderings. Radioembolization with glass (90)Y microspheres was performed. PET/CT imaging (Siemens Biograph 40) was completed with scatter and attenuation correction. 3D ellipsoid VOI were drawn to encompass tumors on fused images. Tumors and livers were then explanted for inductively coupled plasma optical emission spectroscopy (ICP-OES) analysis of microsphere content. (90)Y PET/CT and SM measurements were compared to reference standard ICP-OES measurements of tumor dosing with Pearson correlation and Bland-Altman analyses for agreement testing with and without adjustment for tumor necrosis. RESULTS: The median infused activity was 33.3 MBq (range, 5.9–152.9). The correlation between (90)Y PET/CT measurements and tumor dose was r=0.903 (p |
| Databáze: | OpenAIRE |
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