Dynamic Changes in Numbers and Properties of Circulating Tumor Cells and Their Potential Applications
Autor: | Jeng Kai Jiang, Shu Ching Liang, Ren Shyan Liu, Chi Hung Lin, Ju Yu Tseng, Chih Yung Yang |
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Jazyk: | angličtina |
Rok vydání: | 2014 |
Předmět: |
Metastatic breast
Cancer Research medicine.diagnostic_test business.industry Cancer Review circulating tumor cells medicine.disease Bioinformatics lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Advanced cancer Primary tumor lcsh:RC254-282 Metastasis CTC enrichment and enumeration Circulating tumor cell medicine.anatomical_structure Oncology Prostate Biopsy Cancer research Medicine metastasis business |
Zdroj: | Cancers Cancers, Vol 6, Iss 4, Pp 2369-2386 (2014) |
ISSN: | 2072-6694 |
Popis: | Circulating tumor cells (CTCs) can be detected in the blood of different types of early or advanced cancer using immunology-based assays or nucleic acid methods. The detection and quantification of CTCs has significant clinical utility in the prognosis of metastatic breast, prostate, and colorectal cancers. CTCs are a heterogeneous population of cells and often different from those of their respective primary tumor. Understanding the biology of CTCs may provide useful predictive information for the selection of the most appropriate treatment. Therefore, CTC detection and characterization could become a valuable tool to refine prognosis and serve as a “real-time biopsy” and has the potential to guide precision cancer therapies, monitor cancer treatment, and investigate the process of metastasis. |
Databáze: | OpenAIRE |
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