DNA and protein binding, double-strand DNA cleavage and cytotoxicity of mixed ligand copper(II) complexes of the antibacterial drug nalidixic acid
| Autor: | Mani Ganeshpandian, Anvarbatcha Riyasdeen, Amsaveni Muruganantham, Rangasamy Loganathan, Mohammad Abdulkader Akbarsha, Swapan K. Ghosh, Mallayan Palaniandavar, Nattamai Bhuvanesh |
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| Rok vydání: | 2016 |
| Předmět: |
Stereochemistry
Base pair Apoptosis Breast Neoplasms 010402 general chemistry 01 natural sciences Biochemistry DNA Major Groove Binding Inorganic Chemistry chemistry.chemical_compound Bipyridine Coordination Complexes Humans DNA Breaks Double-Stranded Diimine 010405 organic chemistry Cytotoxins DNA Neoplasm Square pyramidal molecular geometry 0104 chemical sciences Crystallography chemistry Docking (molecular) MCF-7 Cells Female Ethidium bromide DNA Copper |
| Zdroj: | Journal of inorganic biochemistry. 174 |
| ISSN: | 1873-3344 |
| Popis: | The water soluble mixed ligand complexes [Cu(nal)(diimine)(H2O)](ClO4) 1-4, where H(nal) is nalidixic acid and diimine is 2,2'-bipyridine (1), 1,10-phenanthroline (2), 5,6-dimethyl-1,10-phenanthroline (3), and 3,4,7,8-tetramethyl-1,10-phenanthroline (4), have been isolated. The coordination geometry around Cu(II) in 1 and that in the Density Functional Theory optimized structures of 1-4 has been assessed as square pyramidal. The trend in DNA binding constants (Kb) determined using absorption spectral titration (Kb: 1, 0.79±0.1 |
| Databáze: | OpenAIRE |
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