CRISPR Cas System: An efficient tool for cancer modelling
Autor: | Shah Rukh Khan, Mudassir Khan, Mehran Akhtar, Tazkira Jamal, Fazal Jalil, Shohra Haider |
---|---|
Rok vydání: | 2021 |
Předmět: |
Gene Editing
medicine.medical_specialty business.industry Mechanism (biology) Cancer General Medicine medicine.disease Data science Cancer genetics Molecular genetics Neoplasms Medicine CRISPR Humans Narrative review Clustered Regularly Interspaced Short Palindromic Repeats Cancer biology CRISPR-Cas Systems business |
Zdroj: | JPMA. The Journal of the Pakistan Medical Association. 71(2(B)) |
ISSN: | 0030-9982 |
Popis: | The Clustered Regularly Interspaced Short Palindromic Repeats-Cas-9 (CRISPR-Cas9) system has been a revolutionising tool in the field of molecular genetics, which provides a versatile range of editing potentials. Researchers can produce breaks or alter genomes with ease using the system. Cancer is one of the multi-gene diseases whose genes need to be studied in detail. The CRISPR-Cas9 technology may also provide a promising potential in the field of cancer genetics. The current narrative review comprised 50 research articles which were keenly analysed and the applications and outcomes of CRISPR-Cas9 system in cancer genetics were comprehensively and critically discussed. It was concluded that application of the system had great potential to help understand cancer biology of various types and could be used for its genetic modelling. However, much work is still needed to be done to apply the technology for understanding the mechanism of cancers and to help in the designing of appropriate therapies. |
Databáze: | OpenAIRE |
Externí odkaz: |