Withanolide Z, a New Chlorinated Withanolide fromWithania somnifera
| Autor: | Sibabrata Mukhopadhyay, Hemanta K. Majumder, Amit Roy, Shekher Ghosh, Swapan Pramanick |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Stereochemistry
Pharmaceutical Science Withania Biology Pharmacognosy Withania somnifera Analytical Chemistry chemistry.chemical_compound Drug Discovery Animals Withanolide Z Withanolides Pharmacology chemistry.chemical_classification Preparative hplc Molecular Structure Organic Chemistry biology.organism_classification Complementary and alternative medicine chemistry Withanolide Withaferin A Molecular Medicine DNA Topoisomerase I Topoisomerase I Inhibitors Lactone Leishmania donovani |
| Zdroj: | Planta Medica. 74:1745-1748 |
| ISSN: | 1439-0221 0032-0943 |
| DOI: | 10.1055/s-2008-1081357 |
| Popis: | Reverse-phase preparative HPLC analysis of the N-butanol fraction of the methanolic extract of WITHANIA SOMNIFERA Dunal (leaves) afforded a novel chlorinated withanolide, namely withanolide Z ( 1), along with four known withanolides, withanolide B ( 2), withanolide A ( 3), 27-hydroxywithanolide B ( 4) and withaferin A ( 5). Their structures were elucidated by IR, MS, CD and a combination of 1 D and 2 D NMR spectral analyses. The LEISHMANIA DONOVANI DNA topoisomerase I inhibitory activities of the isolated compounds were determined. |
| Databáze: | OpenAIRE |
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