Interventions of aqueous extract of Solanum melongena fruits (garden eggs) on mercury chloride induced testicular toxicity in adult male Wistar rats
| Autor: | O Omotoso, Julius Akomaye Aniah, Sunday Aderemi Adelakun, Grace T. Akingbade, Victor Okoliko Ukwenya |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Mercury chloride Biology Semen analysis medicine.disease_cause Antioxidants Superoxide dismutase Andrology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Chlorides Malondialdehyde Testis medicine Animals Solanum melongena Rats Wistar lcsh:QH301-705.5 Sperm motility chemistry.chemical_classification lcsh:R5-920 medicine.diagnostic_test Glutathione peroxidase Mercury General Medicine Glutathione Sperm Oxidative Stress 030104 developmental biology Garden eggs lcsh:Biology (General) chemistry Fruit 030220 oncology & carcinogenesis Mercuric Chloride Sperm Motility biology.protein Original Article lcsh:Medicine (General) Oxidative stress |
| Zdroj: | Biomedical Journal, Vol 43, Iss 2, Pp 174-182 (2020) Biomedical Journal |
| ISSN: | 2319-4170 |
| DOI: | 10.1016/j.bj.2019.07.004 |
| Popis: | Background Solanum melongena (SM) is commonly known as the garden egg fruit or eggplant. It can be eaten fresh or cooked and has a large history of consumption in West Africa. This study focused on interventions of aqueous extract of SM (garden eggs) fruits on Mercury chloride (HgCl2) induced testicular toxicity in adult male Wistar rats. Methods Thirty-two adult male Wistar rats were randomly divided into four groups (A-D) of eight (n = 8) rats each. Group A Served as control and was given 10 ml/kg/day of distilled water, Group B- 500 mg/kg B.W of SM, Group C received 40 mg/kg B.W HgCl2 and Group D- 500 mg/kg B.W of SM and 40 mg/kg B.W HgCl2). The administration was done by gastric gavage once a day, for twenty-eight consecutive days. Testicular weight, semen analysis revealing the sperm count and sperm motility were assessed, gross parameters of the testis and testicular histology were assessed. Testicular oxidative stress markers viz a viz malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and reduced glutathione (GSH) were also assessed. Results assessment of the histological profiles of the testes showed a derangement of the cytoarchitecture and deterioration of sperm quality after HgCl2 administration and a marked improvement was observed after SM administration. Similarly, SM was associated with increased antioxidant parameters (SOD, CAT, GPx, and GSH) and decreased MDA in SM + HgCl2 rats. Conclusion It was concluded that S. melongena offers protection against free radical mediated oxidative stress of rats with mercury chloride induced testicular toxicity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|