Impact of Sulfadoxine-Pyrimethamine Resistance on Effectiveness of Intermittent Preventive Therapy for Malaria in Pregnancy at Clearing Infections and Preventing Low Birth Weight
| Autor: | Ebbie Chaluluka, Kephas Otieno, Kassoum Kayentao, Feiko O. ter Kuile, Sheick Oumar Coulibaly, Emmanuel Arinaitwe, Meghna Desai, Ya Ping Shi, Ryan E. Wiegand, Peter Ouma, Steve Meshnick, Don P. Mathanga, Kimberly E. Mace, Ogobara K. Doumbo, Jacek Skarbinski, Julie Gutman, Steve M. Taylor, Carole Khairallah, Dabira Edgar, Linda Kalilani, Mulakwa Kamuliwo, Veronica Ades, Pascal Magnussen |
|---|---|
| Přispěvatelé: | Other departments |
| Rok vydání: | 2015 |
| Předmět: |
Microbiology (medical)
Adult medicine.medical_specialty Sulfadoxine medicine.medical_treatment Birth weight 030231 tropical medicine Plasmodium falciparum Drug Resistance Drug resistance Article 03 medical and health sciences Antimalarials Young Adult 0302 clinical medicine Drug Therapy Pregnancy Internal medicine parasitic diseases medicine Humans 030212 general & internal medicine Prospective Studies Pregnancy Complications Infectious Africa South of the Sahara Dihydropteroate Synthase Intermittent preventive therapy business.industry Infant Newborn Infant Low Birth Weight medicine.disease Sulfadoxine/pyrimethamine Malaria Low birth weight Drug Combinations Infectious Diseases Pyrimethamine Treatment Outcome Amino Acid Substitution Immunology Female Mutant Proteins medicine.symptom business medicine.drug |
| Zdroj: | Clinical infectious diseases, 62(3), 323-333. Oxford University Press |
| ISSN: | 1537-6591 1058-4838 |
| Popis: | Background: Owing to increasing sulfadoxine-pyrimethamine (SP) resistance in sub-Saharan Africa, monitoring the effectiveness of intermittent preventive therapy in pregnancy (IPTp) with SP is crucial. Methods: Between 2009 and 2013, both the efficacy of IPTp-SP at clearing existing peripheral malaria infections and the effectiveness of IPTp-SP at reducing low birth weight (LBW) were assessed among human immunodeficiency virus–uninfected participants in 8 sites in 6 countries. Sites were classified as high, medium, or low resistance after measuring parasite mutations conferring SP resistance. An individual-level prospective pooled analysis was conducted. Results: Among 1222 parasitemic pregnant women, overall polymerase chain reaction–uncorrected and –corrected failure rates by day 42 were 21.3% and 10.0%, respectively (39.7% and 21.1% in high-resistance areas; 4.9% and 1.1% in low-resistance areas). Median time to recurrence decreased with increasing prevalence of Pfdhps-K540E. Among 6099 women at delivery, IPTp-SP was associated with a 22% reduction in the risk of LBW (prevalence ratio [PR], 0.78; 95% confidence interval [CI], .69–.88; P < .001). This association was not modified by insecticide-treated net use or gravidity, and remained significant in areas with high SP resistance (PR, 0.81; 95% CI, .67–.97; P = .02). Conclusions: The efficacy of SP to clear peripheral parasites and prevent new infections during pregnancy is compromised in areas with >90% prevalence of Pfdhps-K540E. Nevertheless, in these high-resistance areas, IPTp-SP use remains associated with increases in birth weight and maternal hemoglobin. The effectiveness of IPTp in eastern and southern Africa is threatened by further increases in SP resistance and reinforces the need to evaluate alternative drugs and strategies for the control of malaria in pregnancy. |
| Databáze: | OpenAIRE |
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