Coronary angiography after cardiac arrest: Rationale and design of the COACT trial

Autor: Lucia S.D. Jewbali, Paul W. G. Elbers, Georgios J. Vlachojannis, Nina W. van der Hoeven, Jan G.P. Tijssen, Martin G. Stoel, Martijn Meuwissen, Joris J. van der Heijden, Gladys N. Janssens, Koen Nieman, Raoul M. van der Vleugel, Maarten A. Vink, Pim van der Harst, Tom A. Rijpstra, Harry J.G.M. Crijns, Michiel Voskuil, José P.S. Henriques, Hans A. Bosker, Gabe B. Bleeker, Cyril Camaro, Niels van Royen, Heleen M. Oudemans-van Straaten, Marcel Gosselink, Remon Baak, Jorrit S. Lemkes, Bert Beishuizen, Luuk C. Otterspoor
Přispěvatelé: Cardiology, ICaR - Ischemia and repair, Intensive care medicine, Other departments, Radiology & Nuclear Medicine, Cardiovascular Centre (CVC), RS: CARIM - R2.01 - Clinical atrial fibrillation, Cardiologie, MUMC+: MA Cardiologie (9)
Rok vydání: 2016
Předmět:
Adult
medicine.medical_specialty
THERAPEUTIC HYPOTHERMIA
medicine.medical_treatment
030204 cardiovascular system & hematology
Coronary Angiography
Ventricular tachycardia
Time-to-Treatment
law.invention
03 medical and health sciences
Percutaneous Coronary Intervention
0302 clinical medicine
Randomized controlled trial
law
Internal medicine
STENT THROMBOSIS
medicine
Clinical endpoint
MANAGEMENT
Journal Article
Humans
ST-SEGMENT ELEVATION
Prospective Studies
Renal replacement therapy
Myocardial infarction
cardiovascular diseases
business.industry
RESUSCITATION
ELEVATION MYOCARDIAL-INFARCTION
Percutaneous coronary intervention
030208 emergency & critical care medicine
medicine.disease
Intensive care unit
POSTRESUSCITATION CARE
Intention to Treat Analysis
Multicenter Study
Research Design
Conventional PCI
Randomized Controlled Trial
Cardiology
IMMEDIATE
COMATOSE SURVIVORS
Cardiology and Cardiovascular Medicine
business
INTERVENTION
Out-of-Hospital Cardiac Arrest
Zdroj: The American Heart Journal, 180, 39-45
American Heart Journal, 180, 39. Mosby Inc.
American heart journal, 180, 39-45. Mosby Inc.
Lemkes, J S, Janssens, G N, Oudemans-van Straaten, H M, Elbers, P W, van der Hoeven, N W, Tijssen, J G P, Otterspoor, L C, Voskuil, M, van der Heijden, J J, Meuwissen, M, Rijpstra, T A, Vlachojannis, G J, van der Vleugel, R M, Nieman, K, Jewbali, L S D, Sleeker, G B, Baak, R, Beishuizen, B, Stoel, M G, van der Harst, P, Camaro, C, Henriques, J P S, Vink, M A, Gosselink, M T M, Bosker, H A, Crijns, H J G M & van Royen, N 2016, ' Coronary angiography after cardiac arrest: Rationale and design of the COACT trial ', The American Heart Journal, vol. 180, pp. 39-45 . https://doi.org/10.1016/j.ahj.2016.06.025
American Heart Journal, 180, 39-45. Mosby Inc.
American Heart Journal, 180, 39-45. MOSBY-ELSEVIER
ISSN: 1097-6744
0002-8703
Popis: Background Ischemic heart disease is a major cause of out-of-hospital cardiac arrest. The role of immediate coronary angiography (CAG) and percutaneous coronary intervention (PCI) after restoration of spontaneous circulation following cardiac arrest in the absence of ST-segment elevation myocardial infarction (STEMI) remains debated.Hypothesis We hypothesize that immediate CAG and PCI, if indicated, will improve 90-day survival in post cardiac arrest patients without signs of STEMI.Design In a prospective, multicenter, randomized controlled clinical trial, 552 post cardiac arrest patients with restoration of spontaneous circulation and without signs of STEMI will be randomized in a 1:1 fashion to immediate CAG and PCI (within 2 hours) versus initial deferral with CAG and PCI after neurological recovery. The primary end point of the study is 90-day survival. The secondary end points will include 90-day survival with good cerebral performance or minor/moderate disability, myocardial injury, duration of inotropic support, occurrence of acute kidney injury, need for renal replacement therapy, time to targeted temperature control, neurological status at intensive care unit discharge, markers of shock, recurrence of ventricular tachycardia, duration of mechanical ventilation, and reasons for discontinuation of treatment.Summary The COACT trial is a multicenter, randomized, controlled clinical study that will evaluate the effect of an immediate invasive coronary strategy in post cardiac arrest patients without STEMI on 90-day survival.
Databáze: OpenAIRE
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