Coronary angiography after cardiac arrest: Rationale and design of the COACT trial
Autor: | Lucia S.D. Jewbali, Paul W. G. Elbers, Georgios J. Vlachojannis, Nina W. van der Hoeven, Jan G.P. Tijssen, Martin G. Stoel, Martijn Meuwissen, Joris J. van der Heijden, Gladys N. Janssens, Koen Nieman, Raoul M. van der Vleugel, Maarten A. Vink, Pim van der Harst, Tom A. Rijpstra, Harry J.G.M. Crijns, Michiel Voskuil, José P.S. Henriques, Hans A. Bosker, Gabe B. Bleeker, Cyril Camaro, Niels van Royen, Heleen M. Oudemans-van Straaten, Marcel Gosselink, Remon Baak, Jorrit S. Lemkes, Bert Beishuizen, Luuk C. Otterspoor |
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Přispěvatelé: | Cardiology, ICaR - Ischemia and repair, Intensive care medicine, Other departments, Radiology & Nuclear Medicine, Cardiovascular Centre (CVC), RS: CARIM - R2.01 - Clinical atrial fibrillation, Cardiologie, MUMC+: MA Cardiologie (9) |
Rok vydání: | 2016 |
Předmět: |
Adult
medicine.medical_specialty THERAPEUTIC HYPOTHERMIA medicine.medical_treatment 030204 cardiovascular system & hematology Coronary Angiography Ventricular tachycardia Time-to-Treatment law.invention 03 medical and health sciences Percutaneous Coronary Intervention 0302 clinical medicine Randomized controlled trial law Internal medicine STENT THROMBOSIS medicine Clinical endpoint MANAGEMENT Journal Article Humans ST-SEGMENT ELEVATION Prospective Studies Renal replacement therapy Myocardial infarction cardiovascular diseases business.industry RESUSCITATION ELEVATION MYOCARDIAL-INFARCTION Percutaneous coronary intervention 030208 emergency & critical care medicine medicine.disease Intensive care unit POSTRESUSCITATION CARE Intention to Treat Analysis Multicenter Study Research Design Conventional PCI Randomized Controlled Trial Cardiology IMMEDIATE COMATOSE SURVIVORS Cardiology and Cardiovascular Medicine business INTERVENTION Out-of-Hospital Cardiac Arrest |
Zdroj: | The American Heart Journal, 180, 39-45 American Heart Journal, 180, 39. Mosby Inc. American heart journal, 180, 39-45. Mosby Inc. Lemkes, J S, Janssens, G N, Oudemans-van Straaten, H M, Elbers, P W, van der Hoeven, N W, Tijssen, J G P, Otterspoor, L C, Voskuil, M, van der Heijden, J J, Meuwissen, M, Rijpstra, T A, Vlachojannis, G J, van der Vleugel, R M, Nieman, K, Jewbali, L S D, Sleeker, G B, Baak, R, Beishuizen, B, Stoel, M G, van der Harst, P, Camaro, C, Henriques, J P S, Vink, M A, Gosselink, M T M, Bosker, H A, Crijns, H J G M & van Royen, N 2016, ' Coronary angiography after cardiac arrest: Rationale and design of the COACT trial ', The American Heart Journal, vol. 180, pp. 39-45 . https://doi.org/10.1016/j.ahj.2016.06.025 American Heart Journal, 180, 39-45. Mosby Inc. American Heart Journal, 180, 39-45. MOSBY-ELSEVIER |
ISSN: | 1097-6744 0002-8703 |
Popis: | Background Ischemic heart disease is a major cause of out-of-hospital cardiac arrest. The role of immediate coronary angiography (CAG) and percutaneous coronary intervention (PCI) after restoration of spontaneous circulation following cardiac arrest in the absence of ST-segment elevation myocardial infarction (STEMI) remains debated.Hypothesis We hypothesize that immediate CAG and PCI, if indicated, will improve 90-day survival in post cardiac arrest patients without signs of STEMI.Design In a prospective, multicenter, randomized controlled clinical trial, 552 post cardiac arrest patients with restoration of spontaneous circulation and without signs of STEMI will be randomized in a 1:1 fashion to immediate CAG and PCI (within 2 hours) versus initial deferral with CAG and PCI after neurological recovery. The primary end point of the study is 90-day survival. The secondary end points will include 90-day survival with good cerebral performance or minor/moderate disability, myocardial injury, duration of inotropic support, occurrence of acute kidney injury, need for renal replacement therapy, time to targeted temperature control, neurological status at intensive care unit discharge, markers of shock, recurrence of ventricular tachycardia, duration of mechanical ventilation, and reasons for discontinuation of treatment.Summary The COACT trial is a multicenter, randomized, controlled clinical study that will evaluate the effect of an immediate invasive coronary strategy in post cardiac arrest patients without STEMI on 90-day survival. |
Databáze: | OpenAIRE |
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