Cholesterol metabolism during the growth of a rat ascites hepatoma (Yoshida AH-130)
| Autor: | Sandro Dessi, Batetta B, P. Pani, Luciana Tessitore, Paola Costelli, Francesco M. Baccino, Carlo Anchisi |
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| Rok vydání: | 1992 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Time Factors Lipoproteins VLDL Biology Tritium chemistry.chemical_compound Liver Neoplasms Experimental Blood serum Internal medicine Ascites medicine Animals Rats Wistar Chromatography High Pressure Liquid Tumor Necrosis Factor-alpha Cholesterol Body Weight Reverse cholesterol transport Blood Proteins DNA Neoplasm Metabolism Lipids Blood proteins Neoplasm Proteins Rats Lipoproteins LDL Molecular Weight Endocrinology Oncology chemistry lipids (amino acids peptides and proteins) Tumor necrosis factor alpha medicine.symptom Lipoproteins HDL Cell Division Neoplasm Transplantation Intracellular Research Article Thymidine |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | The metabolism of cholesterol has been investigated in tumour cells, ascitic fluid and blood serum during the growth of an ascites hepatoma (Yoshida AH-130) in the rat. High rates of cholesterol synthesis and elevated free and esterified cholesterol content were observed in tumour cells. During tumour growth, the host animals progressively developed marked changes in the level and distribution of serum cholesterol consisting in an increase of total cholesterol and of a marked reduction of HDL cholesterol (HDL2 subfraction in particular). In agreement with previous observations, these findings indicate that a consistent pattern of altered cholesterol homeostasis develops in relation to normal or neoplastic tissue growth. High synthetic rates and intracellular accumulation of cholesterol are observed in the proliferating cells. Moreover, blood serum cholesterol decreases in the HDL fraction while it increases in LDLs, suggesting that during proliferative processes cholesterol fluxes between tissues and serum lipoproteins are markedly perturbed. |
| Databáze: | OpenAIRE |
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