Surface-modified protein nanospheres as potential antiviral agents

Autor:	Aharon Gedanken, Shai Rahimipour, Dana Baram-Pinto, Sourabh Shukla, Ronit Sarid, Michal Richman
Rok vydání:	2012
Předmět:	Surface Properties Herpesvirus 1 Human Conjugated system Antiviral Agents Catalysis chemistry.chemical_compound Materials Chemistry Animals Organic chemistry Bovine serum albumin Cells Cultured Mercaptoethanol Dose-Response Relationship Drug biology Chemistry Surface modified Metals and Alloys Serum Albumin Bovine General Chemistry Heparan sulfate Combinatorial chemistry Surfaces Coatings and Films Electronic Optical and Magnetic Materials Sulfonate Covalent bond Ceramics and Composites biology.protein Cattle Sulfonic Acids Nanospheres
Zdroj:	Chemical Communications. 48:8359
ISSN:	1364-548X 1359-7345
DOI:	10.1039/c2cc33448h
Popis:	A novel application of surface-modified protein nanospheres as potential antiviral agents is illustrated. By using a single-step sonochemical process, bovine serum albumin nanospheres were generated, whose surface was covalently conjugated with mercaptoethane sulfonate to chemically and electrostatically mimic cellular heparan sulfate. The nanospheres effectively inhibited HSV-1 infection.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::738df7121187479c7c4d559f83ab1fcc https://doi.org/10.1039/c2cc33448h Zobrazit plný text záznamu