Pathology of immunoglobulins some aspects of monoclonal gammopathy
| Autor: | J. W. Stoop, R. E. Ballieux, N. A. J. Mul, Ben J.M. Zegers, J.W. Imhof |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1968 |
| Předmět: |
Pathology
medicine.medical_specialty Blood Protein Disorders Clinical Biochemistry Disease Biochemistry Geneeskunde medicine Humans Clinical significance Multiple myeloma Blood Cells biology business.industry Biochemistry (medical) General Medicine medicine.disease Clone Cells Monoclonal gammopathy Immunoglobulin M Immunoglobulin G Monoclonal biology.protein gamma-Globulins medicine.symptom Antibody Clone (B-cell biology) business Multiple Myeloma Peptides Nephelometry Ultracentrifugation |
| Zdroj: | Clinica Chimica Acta, 22(1), 7. Elsevier |
| ISSN: | 0009-8981 |
| Popis: | Human immunoglobulins are a heterogeneous group of proteins closely related in biological function and highly similar in molecular structure. The immunoglobulins are synthesized in cells of the lymphoreticular system. Antigenic stimulation will produce a reaction in the lymphoreticular system in which many different cell clones are involved. This ensures a diffuse increase of immunoglobulins: a $olyclonal reactionl. Malignant proliferation of a single clone will cause excessive production of a homogeneous immunoglobulin fraction: a monoclonal gammopathyl. One of the aspects of monoclonal gammopathy, viz the presence of an M-component in serum or urine, is the fact that the term “M-component” has begun to lead pretty much its own life as a result of the enormous advances in immunology and profound analytical studies of immunoglobulin structures. Today the term far exceeds its clinical significance. Thus one may find an extensive literature which discusses monoclonal gammopathy as if it were a disease. It is well-advised to bear in mind, however, that one is only dealing with a symptom. The extent to which clinical insights have lagged behind laboratory findings can be illustrated by referring to the fact that, not too long ago, the finding of an M-component was practically tantamount to a diagnosis of multiple myeloma or Waldenstrom’s macroglobulinaemia. But in the years between 1950 and 1960 this simple equation was no longer valid when monoclonal gammopathy was also found to occur in other syndromes2-6. |
| Databáze: | OpenAIRE |
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