Absorption of ingested talc by hamsters
| Autor: | T.M. Tanner, R.L. Buschbom, A.P. Wehner |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
medicine.medical_specialty
Mesocricetus Inhalation Chemistry digestive oral and skin physiology Urine Absorption (skin) Toxicology Talc Intestinal absorption Surgery Feces Animal science Urinary excretion Intestinal Absorption Cricetinae medicine Animals Female Digestive System Physiological saline medicine.drug |
| Zdroj: | Food and Cosmetics Toxicology. 15:453-455 |
| ISSN: | 0015-6264 |
| DOI: | 10.1016/s0015-6264(77)80013-8 |
| Popis: | Summary To determine talc absorption in the gastro-intestinal tract of hamsters, talc was neutron-activated and suspended in physiological saline and 1-ml aliquots of this suspension were administered by gastric intubation to six 10-wk-old Syrian golden hamsters, which were kept in metabolism cages. The hamsters were killed 24 hr after gavage, and the skinned carcass, gastro-intestinal tract, lungs, liver, kidneys and collected urine and faeces were analysed for 60 Co and 46 Sc by γ -ray spectrometry. An average of approximately 3 mg talc was found in the tissues and excreta. Of this quantity, 74.5% was found in the faeces, 23.5% in the gut and 1.9% in the carcass. The γ-ray counts from the urine, accounting for 0.09% of the total, were probably due to leaching of 60 Co from the talc with subsequent absorption and urinary excretion. This study shows that intestinal absorption of talc is negligible and could have contributed only minimally to the body burden of talc found in hamsters in a previously published inhalation study. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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