Daily and Alternate-Day Corticosteroid Regimens in Treatment of Giant Cell Arteritis
| Autor: | Sheldon G. Sheps, Gene G. Hunder, George L. Allen, John W. Joyce |
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| Rok vydání: | 1975 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Biopsy Giant Cell Arteritis Statistics as Topic Gastroenterology law.invention Randomized controlled trial law Prednisone Internal medicine Internal Medicine Humans Medicine Prospective Studies Arteritis Prospective cohort study Aged business.industry General Medicine Middle Aged medicine.disease Temporal Arteries Every Morning Giant cell arteritis Regimen Corticosteroid Female business medicine.drug |
| Zdroj: | Annals of Internal Medicine. 82:613 |
| ISSN: | 0003-4819 |
| Popis: | Alternate-day corticosteroid therapy was compared with two daily corticosteroid regimens for the treatment of giant cell arteritis. In a prospective study 60 patients with this disease were randomly assigned to three treatment groups: group A, 15 mg of prednisone every 8 hours; group B, 45 mg of prednisone every morning; and group C, 90 mgof prednisone every other morning. After 1 month of treatment, the arteritis seemed to be completely suppressed in 18 patients in group A and 16 in group B but in only 6 in group C. In the 14 other patients in group C, the continuing symptoms were cyclic and developed during the day steroids were not given. By changing to a daily regimen, the arteritis was controlled in most patients in group C. Adverse reactions to prednisone were noted frequently in groups A and B but rarely in group C. |
| Databáze: | OpenAIRE |
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