Central Control Circuit for Context-Dependent Micturition
| Autor: | Minsuk Hyun, Julian Taranda, Pavel Osten, Mark L. Zeidel, Danielle Feng, Kee Wui Huang, Emily Atwater, Emmalee Todd, Bernardo L. Sabatini, Xun Helen Hou, Donyell M Croney |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Corticotropin-Releasing Hormone media_common.quotation_subject Urinary Bladder Glutamic Acid Urination Context (language use) Olfaction Biology General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences Glutamatergic Corticotropin-releasing hormone Mice 0302 clinical medicine Pons medicine Animals media_common Neurons Spinal cord Mice Inbred C57BL Smell 030104 developmental biology medicine.anatomical_structure Spinal Cord Female Barrington's Nucleus Neuroscience 030217 neurology & neurosurgery Muscle Contraction |
| Zdroj: | Cell. 167(1) |
| ISSN: | 1097-4172 |
| Popis: | Urine release (micturition) serves an essential physiological function as well as a critical role in social communication in many animals. Here, we show a combined effect of olfaction and social hierarchy on micturition patterns in adult male mice, confirming the existence of a micturition control center that integrates pro- and anti-micturition cues. Furthermore, we demonstrate that a cluster of neurons expressing corticotropin-releasing hormone (Crh) in the pontine micturition center (PMC) is electrophysiologically distinct from their Crh-negative neighbors and sends glutamatergic projections to the spinal cord. The activity of PMC Crh-expressing neurons correlates with and is sufficient to drive bladder contraction, and when silenced impairs micturition behavior. These neurons receive convergent input from widespread higher brain areas that are capable of carrying diverse pro- and anti-micturition signals, and whose activity modulates hierarchy-dependent micturition. Taken together, our results indicate that PMC Crh-expressing neurons are likely the integration center for context-dependent micturition behavior. |
| Databáze: | OpenAIRE |
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