Effect of dietary n-3 polyunsaturated fatty acids on plasma total and high-molecular-weight adiponectin concentrations in overweight to moderately obese men and women

Autor: Mario Kratz, Peter J. Havel, Holly S. Callahan, Michael M. Swarbrick, Colleen C. Matthys, David S. Weigle
Rok vydání: 2008
Předmět:
Male
obesity
Medicine (miscellaneous)
Adipose tissue
Overweight
Cardiovascular
Severity of Illness Index
Medical and Health Sciences
n-3
Oral and gastrointestinal
Engineering
Weight loss
Medicine
Cancer
chemistry.chemical_classification
Omega-3
Nutrition and Dietetics
food and beverages
Fasting
Middle Aged
Stroke
Adipose Tissue
Female
Adiponectin
Analysis of variance
medicine.symptom
Polyunsaturated fatty acid
Adult
medicine.medical_specialty
fatty acids
Article
Clinical Research
Internal medicine
Fatty Acids
Omega-3
Weight Loss
Complementary and Integrative Health
Humans
overweight
Obesity
Metabolic and endocrine
Nutrition
Analysis of Variance
adiponectin
Nutrition & Dietetics
business.industry
Prevention
Body Weight
medicine.disease
Dietary Fats
Molecular Weight
Endocrinology
chemistry
business
Energy Intake
diet
Body mass index
Biomarkers
Zdroj: The American journal of clinical nutrition, vol 87, iss 2
Kratz, Mario; Swarbrick, Michael M; Callahan, Holly S; Matthys, Colleen C; Havel, Peter J; & Weigle, David S. (2008). Effect of dietary n-3 polyunsaturated fatty acids on plasma total and high-molecular-weight adiponectin concentrations in overweight to moderately obese men and women.. The American journal of clinical nutrition, 87(2), 347-353. doi: 10.1093/ajcn/87.2.347. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/6351p9wd
DOI: 10.1093/ajcn/87.2.347.
Popis: BackgroundRecent studies indicated that dietary n-3 polyunsaturated fatty acids (PUFAs) increase circulating adiponectin concentrations in rodents.ObjectiveWe aimed to investigate whether a diet rich in n-3 PUFAs increased plasma concentrations of total or high-molecular-weight (HMW) adiponectin in healthy overweight-to-moderately obese men and women.DesignSixteen women and 10 men with a body mass index (in kg/m(2)) between 28 and 33 were randomly assigned to consume a diet rich in n-3 PUFAs (3.5% of energy intake) from both plant and marine sources or a control diet (0.5% of energy intake from n-3 PUFAs). For the first 2 wk, these diets were consumed under isocaloric conditions; then followed a 12-wk period of ad libitum consumption that was associated with a moderate loss of approximately 3.5% of body weight in both groups. Total and HMW adiponectin plasma concentrations were measured before and after each diet phase.ResultsPlasma fasting adiponectin concentrations did not change during the isocaloric period, but they increased modestly ( approximately 10%) during the ad libitum period when subjects lost weight [P = 0.009 for time in repeated-measures analysis of variance] and to a similar extent in subjects consuming the control (x +/- SD: 0.42 +/- 0.69 microg/mL) and n-3 PUFA (0.45 +/- 0.85 microg/mL) diets (P = 0.920 for time x treatment interaction). Plasma concentrations of HMW adiponectin did not change significantly during the study.ConclusionDietary n-3 PUFAs consumed at levels of 3.5% of energy intake do not significantly increase plasma or HMW adiponectin concentrations in overweight-to-moderately obese healthy men and women over the course of 14 wk.
Databáze: OpenAIRE
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