New Class of Competitive Inhibitor of Bacterial Histidine Kinases
| Autor: | Anna Riley, Qin Sheng, Dalai Yan, Kenneth James Junior Henry, J. Estelle Foster, Pei-Ming Sun, Malcolm E. Winkler, Wai-Leung Ng, Raymond Gilmour, Thalia I. Nicas, Jonathan R. McClain |
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| Rok vydání: | 2005 |
| Předmět: |
chemistry.chemical_classification
Dose-Response Relationship Drug Histidine Kinase biology Pyridines Kinase Histidine kinase biology.organism_classification Microbiology Serine Enzyme Bacterial Proteins Biochemistry chemistry Bacteriology Enzyme Inhibitors Threonine Protein Kinases Molecular Biology Bacteria Histidine Signal Transduction |
| Zdroj: | Journal of Bacteriology. 187:8196-8200 |
| ISSN: | 1098-5530 0021-9193 |
| DOI: | 10.1128/jb.187.23.8196-8200.2005 |
| Popis: | Bacterial histidine kinases have been proposed as targets for the discovery of new antibiotics, yet few specific inhibitors of bacterial histidine kinases have been reported. We report here a novel thienopyridine (TEP) compound that inhibits bacterial histidine kinases competitively with respect to ATP but does not comparably inhibit mammalian serine/threonine kinases. Although it partitions into membranes and does not inhibit the growth of bacterial or mammalian cells, TEP could serve as a starting compound for a new class of histidine kinase inhibitors with antibacterial activity. |
| Databáze: | OpenAIRE |
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