Is there any increased risk of hypertension, diabetes and cardiac diseases in psoriatic patients with TNF-α G238A and G308A polymorphism?
| Autor: | Sevilay Kiliç, Zerrin Ogretmen, Fatma Silan, Meliha Merve Hiz, Selda Işik |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
G298A
medicine.medical_specialty Turkish population lcsh:Internal medicine hypertension Dermatology Disease tumor necrosis factor α Gastroenterology Coronary artery disease 03 medical and health sciences 0302 clinical medicine Internal medicine Psoriasis Diabetes mellitus medicine lcsh:Dermatology Immunology and Allergy 030212 general & internal medicine lcsh:RC31-1245 Tumor necrosis factor α Autoimmune disease Original Paper diabetes business.industry psoriasis G308A lcsh:RL1-803 medicine.disease 030220 oncology & carcinogenesis Tumor necrosis factor alpha business |
| Zdroj: | Advances in Dermatology and Allergology, Vol 33, Iss 6, Pp 440-444 (2016) Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii |
| ISSN: | 2299-0046 |
| Popis: | Introduction : Psoriasis is regarded as a complex autoimmune disease with strong genetic background. Psoriatic patients suffer from many comorbidities including hypertension, diabetes and cardiovascular diseases. Cytokines such as tumor necrosis factor α (TNF-α) may be a key player that triggers psoriasis and diabetes, hypertension and cardiac disease at the same time. Aim: To evaluate genetic variations in the TNF-α region and its association with psoriasis and related comorbidities. Material and methods : The study covered 129 psoriasis patients with three main subgroups with coronary artery disease (n = 41), hypertension (n = 35), and diabetes (n = 21). DNA samples were genotyped for TNF-α G308A and G238A polymorphisms by real-time polymerase chain reaction melting-curve analysis and results were compared statistically. Results : Psoriatic patients with both TNF-α-298 and TNF-α-308 polymorphisms showed no statistically significant increase in the risk of hypertension (OR = 0.425, χ 2 = 1.76, p = 0.18 and OR = 1.87,χ 2 = 1.33, p = 0.25), coronary artery disease (OR = 1.97, χ 2 = 1.91, p = 0.17 and OR = 2.63, χ 2 = 1.35, p = 0.25), or diabetes (OR = 1.35, χ 2 = 0.24, p = 0.62 and OR = 1.53, χ 2 = 0.24, p = 0.62). Conclusions : The current preliminary results suggested that there was no correlation between TNF- promoter polymorphism and diabetes, hypertension and cardiac disease among psoriatic patients in the Turkish population. |
| Databáze: | OpenAIRE |
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