Head-to-Head Comparison of Anti-Inflammatory Performance of Known Natural Products In Vitro
| Autor: | Allijn, Iris E., Vaessen, Stefan F C, Quarles Van Ufford, Linda C., Beukelman, Kees J., De Winther, Menno P J, Storm, G, Schiffelers, Raymond M., Sub General Pharmaceutics, Sub Medicinal Chemistry & Chemical biol., Sub Drug targeting, Pharmaceutics, Medicinal Chemistry and Chemical Biology |
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| Přispěvatelé: | Sub General Pharmaceutics, Sub Medicinal Chemistry & Chemical biol., Sub Drug targeting, Pharmaceutics, Medicinal Chemistry and Chemical Biology, Biomaterials Science and Technology, Faculty of Science and Technology, Amsterdam Cardiovascular Sciences, Amsterdam institute for Infection and Immunity, Medical Biochemistry |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Berberine Neutrophils Physiology Anti-Inflammatory Agents Glycobiology lcsh:Medicine Pharmacology Epigallocatechin gallate Pathology and Laboratory Medicine Biochemistry Catechin chemistry.chemical_compound Mice White Blood Cells Animal Cells Immune Physiology METIS-318110 Stilbenes Medicine and Health Sciences Medicine lcsh:Science Immune Response media_common Pravastatin Medicine(all) Innate Immune System Multidisciplinary Agricultural and Biological Sciences(all) In vitro toxicology Hematology Berberine Chloride Cytokines medicine.symptom Cellular Types Research Article Drug Blood Platelets Curcumin medicine.drug_class media_common.quotation_subject Prednisolone Inflammatory Diseases Immune Cells Primary Cell Culture Immunology Inflammation Anti-inflammatory Cell Line 03 medical and health sciences Signs and Symptoms Diagnostic Medicine Journal Article Animals Humans Comparative Study Platelet activation Blood Coagulation Secretion Glycoproteins Biological Products Blood Cells business.industry Biochemistry Genetics and Molecular Biology(all) Interleukin-6 Tumor Necrosis Factor-alpha Macrophages lcsh:R Interleukin-8 Acetophenones Biology and Life Sciences Fibrinogen Cell Biology Molecular Development Platelet Activation 030104 developmental biology Mechanism of action chemistry Immune System IR-101556 lcsh:Q Caco-2 Cells business Reactive Oxygen Species Physiological Processes Genetics and Molecular Biology(all) Developmental Biology |
| Zdroj: | PLoS ONE PLoS ONE [E], 11(5). Public Library of Science PLoS ONE, Vol 11, Iss 5, p e0155325 (2016) PLoS One, 11(5). Public Library of Science PLoS ONE, 11(5):e0155325, 1-17. Public Library of Science PLoS ONE, 11(5). Public Library of Science |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0155325 |
| Popis: | Inflammation is an important therapeutic target. Due to their potency, steroidal drugs dominate the current treatment of inflammatory disorders. However, steroidal drugs can also exert a broad range of side effects and appear not always effective. This calls for the development of alternative drugs with a different mechanism of action, which are likely to be found in the field of natural products (NPs). For many NPs strong anti-inflammatory effects have been described, but usually investigating a single compound in a single assay. In this study, eight promising NPs were selected and tested against the strong anti-inflammatory drug prednisolone. For this head-to-head comparison, in vitro assays were used which represent different pathways of the inflammatory response: TNF-α and IL-6 expression by macrophages, IL-8 expression by colon epithelial cells, ROS production in polymorphonuclear leukocytes and platelet activation in whole blood. Performance profiles were established which allowed us to identify curcumin, berberine chloride and epigallocatechin gallate as potential alternatives for prednisolone or other glucocorticoids in inflammation. |
| Databáze: | OpenAIRE |
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