Early systolic lengthening by speckle tracking echocardiography predicts outcome after coronary artery bypass surgery
| Autor: | Sune Pedersen, Rasmus Mogelvang, Peter Søgaard, Tor Biering-Sørensen, Philip Brainin, Søren Galatius, Flemming Javier Olsen, Gunnar Gislason, Allan Iversen, Thomas Fritz-Hansen, Søren Lindberg |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
ESL
early systolic lengthening IDI integrated discrimination improvement medicine.medical_specialty medicine.medical_treatment Speckle tracking echocardiography 030204 cardiovascular system & hematology Revascularization 03 medical and health sciences Coronary artery bypass surgery 0302 clinical medicine Euroscore ii Internal medicine LVEF left ventricular ejection fraction Medicine Diseases of the circulatory (Cardiovascular) system 030212 general & internal medicine A late transmitral inflow velocity LV left ventricular IQR interquartile range Original Paper business.industry Proportional hazards model CABG coronary artery bypass graft E early transmitral inflow velocity Prognosis HR hazard ratio Deformation medicine.anatomical_structure surgical procedures operative Systolic lengthening NRI net reclassification index RC666-701 Cardiology GLS global longitudinal strain CK-MB creatine kinase myocardial band e’ early diastolic tissue velocity Cardiology and Cardiovascular Medicine business Clinical risk factor Early systolic Artery |
| Zdroj: | Brainin, P, Lindberg, S, Olsen, F J, Pedersen, S, Iversen, A, Galatius, S, Fritz-Hansen, T, Gislason, G, Søgaard, P, Møgelvang, R & Biering-Sørensen, T 2021, ' Early systolic lengthening by speckle tracking echocardiography predicts outcome after coronary artery bypass surgery ', IJC Heart and Vasculature, vol. 34, 100799 . https://doi.org/10.1016/j.ijcha.2021.100799 International Journal of Cardiology: Heart & Vasculature, Vol 34, Iss, Pp 100799-(2021) International Journal of Cardiology. Heart & Vasculature |
| DOI: | 10.1016/j.ijcha.2021.100799 |
| Popis: | Highlights • Early systolic lengthening (ESL) is a paradoxical lengthening of myocardial fibers. • Speckle tracking echocardiography is a common imaging tool for assessment of ESL. • ESL was a predictor of cardiovascular and all-cause death in CABG patients. • Specifically, the prognostic value of ESL was enhanced in women undergoing CABG. Background Early systolic lengthening (ESL), a paradoxical stretch of myocardial fibers, has been linked to loss of myocardial viability and contractile dysfunction. We assessed the long-term prognostic potential of ESL in coronary artery bypass graft (CABG) patients. Methods We retrospectively included patients (n = 709; mean age 68 years; 85% men) who underwent speckle tracking echocardiography (median 15 days) prior to CABG. Endpoints were cardiovascular death (CVD) and all-cause mortality. We assessed amplitude of ESL (%), defined as peak positive strain, and duration of ESL (ms), determined as time from Q-wave on the ECG to peak positive strain. We applied Cox models adjusted for clinical risk assessed as EuroSCORE II. Results During median follow-up of 3.8 years [IQR 2.7–4.9 years], 45 (6%) experienced CVD and 80 (11%) died. In survival analyses adjusted for EuroSCORE II, each 1% increase in amplitude of ESL was associated with CVD (HR 1.35 [95%CI 1.09–1.68], P = 0.006) and all-cause mortality (HR 1.29 [95%CI 1.08–1.54], P = 0.004). Similar findings applied to duration of ESL (per 10ms increase) and CVD (HR 1.12 [95%CI 1.02–1.23], P = 0.016) and all-cause mortality (HR 1.09 [95%CI 1.01––1.17], P = 0.031). The prognostic value of ESL amplitude was modified by sex (P interaction |
| Databáze: | OpenAIRE |
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