Endoscopic mucosal autograft for treating esophageal caustic strictures: preliminary human experience
| Autor: | Min Wang, Shoushan Bu, Kexin He, Xiang Wang, Li Liu, Lili Zhao, Zhining Fan |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
medicine.medical_specialty Esophageal Mucosa Normal diet Urethral stricture Endoscopic mucosal resection Endoscopy Gastrointestinal 03 medical and health sciences 0302 clinical medicine Restenosis Burns Chemical medicine Humans Regeneration Autografts Aged Retrospective Studies business.industry Mouth Mucosa Gastroenterology Middle Aged medicine.disease Dilatation Dysphagia Surgery Transplantation Stenosis 030220 oncology & carcinogenesis Esophageal stricture Esophageal Stenosis 030211 gastroenterology & hepatology medicine.symptom Deglutition Disorders business |
| Zdroj: | Endoscopy. 50:1017-1021 |
| ISSN: | 1438-8812 0013-726X |
| Popis: | Background Esophageal caustic stricture is a stubborn disease and postoperative restenosis limits the clinical efficacy of endoscopic dilation. Autologous mucosal grafts have been successfully applied in the treatment of urethral stricture and in the prevention of stricture after extensive mucosal resection. We aimed to use mucosal autografting performed endoscopically to treat refractory esophageal stricture. Methods Three patients with intractable corrosive esophageal stricture were treated endoscopically by combining dilation with autologous mucosal transplantation. Results All procedures were successful with no severe complications. Mucosal regeneration was shown at the transplanted segments. One patient was able to maintain a normal diet with complete remission after 1 year of follow-up. Intraluminal stenosis and dysphagia were significantly improved in another two patients. Conclusions Mucosal autografting can achieve esophageal re-epithelialization, inhibit undesired fibrosis, prevent restenosis, and promote functional regeneration. |
| Databáze: | OpenAIRE |
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