207Pb-1H two-dimensional NMR spectroscopy: a useful new tool for probing lead(II) coordination chemistry
| Autor: | Charlotte L. Stern, M.A. ter Horst, Cameron E. Forde, E.S. Claudio, Hilary A. Godwin, M.K. Zart |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
chemistry.chemical_classification
Aqueous solution Analytical chemistry Charge (physics) Nuclear magnetic resonance spectroscopy Spectral line Environmental - origin Coordination complex Inorganic Chemistry Crystallography chemistry Heteronuclear molecule Physical and Theoretical Chemistry Spectroscopy |
| Zdroj: | Inorganic chemistry. 39(7) |
| ISSN: | 0020-1669 |
| Popis: | Despite the fact that lead poisoning is the most common disease of environmental origin in the US, the spectroscopic properties of aqueous Pb(II) coordination compounds have not been extensively investigated. Spectroscopic techniques that can be used to probe the fundamental coordination chemistry of Pb(II) will aid in both the development of water-soluble ligands that bind lead both tightly and selectively and the characterization of potential biological targets. Here, the authors report the preparation and characterization of a series of Pb(II) complexes of amido derivatives of EDTA. The {sup 207}Pb chemical shift observed in these complexes (2441, 2189, and 1764 ppm for [Pb(EDTA)]{sup 2{minus}}, Pb(EDTA-N{sub 2}), and [Pb(EDTA-N{sub 4})]{sup 2+}, respectively) provides an extremely sensitive measure of the local environment and the charge on each complex. These shifts help to map out the lead chemical shift range that can be expected for biologically relevant sites. In addition, the authors report the first two-dimensional {sup 207}Pb-{sup 1}H heteronuclear multiple-quantum correlation (HMQC) nuclear magnetic resonance spectra and demonstrate that this experiment can provide useful information about the lead coordination environment in aqueous Pb(II) complexes. Because this technique allows {sup 207}Pb-{sup 1}H couplings through three bonds to be identified readily, {sup 207}Pb-{sup 1}H NMRmore » spectroscopy should prove useful for the investigation of Pb(II) in more complex systems (e.g., biological and environmental samples).« less |
| Databáze: | OpenAIRE |
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