Chromosomal aberrations by comparative genomic hybridization in thyroid tumors in patients with familial nonmedullary thyroid cancer
| Autor: | Gregg Magrane, Quan-Yang Duh, Orlo H. Clark, Nobuyuki Wada, Rasa Zarnegar, Mariwil G. Wong, Orrin Davis, Laurent Brunaud |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Somatic cell Endocrinology Diabetes and Metabolism Biology Genome Germline Endocrinology Gene Frequency medicine Humans In patient Thyroid Neoplasms Thyroid cancer Thyroid tumors Aged Aged 80 and over Chromosome Aberrations Sex Characteristics Thyroid Chromosome Mapping Nucleic Acid Hybridization Middle Aged medicine.disease medicine.anatomical_structure Female Comparative genomic hybridization |
| Zdroj: | Thyroid : official journal of the American Thyroid Association. 13(7) |
| ISSN: | 1050-7256 |
| Popis: | Nonmedullary thyroid cancer is the most common form of thyroid cancer and its familial form (FNMTC) is increasingly recognized as a distinct clinical entity. However, the genetic background of FNMTC is still poorly understood and the causative gene(s) have not yet been identified.Because comparative genomic hybridization allows for screening of the entire tumor genome simultaneously for chromosomal gains and/or losses without prior knowledge of potential aberrations, we used this technique in thyroid normal and neoplastic samples from FNMTC patients (1) to analyze whether chromosomal aberrations would correlate with inheritance pattern, and/or clinicopathologic features and (2) to compare comparative genomic hybridization (CGH) findings in familial tumors with those already known in sporadic differentiated thyroid cancers.No common germline or somatic chromosomal aberrations were observed in patients with FNMTC because the frequencies and most locations of chromosomal aberrations in familial tumors were also common in sporadic tumors. However, some somatic aberrations were only found in familial tumors (gains in 2q, 3q, 18p, and 19p). Common aberrations in familial tumors corresponded to several locations of candidate genes already reported for sporadic thyroid tumorigenesis.Our findings suggest that chromosomal aberrations in thyroid tumors in patients with FNMTC are not related to inheritance pattern but rather to tumorigenesis. |
| Databáze: | OpenAIRE |
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