Rates of hospitalization and death for all-cause and rotavirus acute gastroenteritis before rotavirus vaccine introduction in Kenya, 2010–2013

Autor:	Billy Ogwel, Richard Omore, J. Pekka Nuorti, Jane Juma, Sammy Khagayi, Robert F. Breiman, John B. Ochieng, Umesh D. Parashar, Collins Tabu, Stephen Munga, Jason M. Mwenda, Sergon Kibet, Frank Odhiambo, Jacqueline E. Tate, Reuben Onkoba
Přispěvatelé:	Yhteiskuntatieteiden tiedekunta - Faculty of Social Sciences, Tampere University
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Adult Male 0301 basic medicine Rotavirus Pediatrics medicine.medical_specialty Adolescent Biolääketieteet - Biomedicine 030106 microbiology medicine.disease_cause Rotavirus Infections lcsh:Infectious and parasitic diseases Feces 03 medical and health sciences 0302 clinical medicine medicine Humans Terveystiede - Health care science lcsh:RC109-216 030212 general & internal medicine Mortality Child Children Disease burden Immunization Programs business.industry Mortality rate Infant Newborn Rotavirus Vaccines Infant Middle Aged Kenya Verbal autopsy Rotavirus vaccine Kenyan Gastroenteritis Hospitalization Infectious Diseases Child Preschool Tropical medicine Vomiting Female Autopsy medicine.symptom Morbidity business Loose Stool Research Article
Zdroj:	BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-11 (2019) BMC Infectious Diseases
ISSN:	1471-2334
DOI:	10.1186/s12879-018-3615-6
Popis:	Background Rotavirus vaccine was introduced in Kenya immunization program in July 2014. Pre-vaccine disease burden estimates are important for assessing vaccine impact. Methods Children with acute gastroenteritis (AGE) (≥3 loose stools and/or ≥ 1 episode of unexplained vomiting followed by loose stool within a 24-h period), hospitalized in Siaya County Referral Hospital (SCRH) from January 2010 through December 2013 were enrolled. Stool specimens were tested for rotavirus (RV) using an enzyme immunoassay (EIA). Hospitalization rates were calculated using person-years of observation (PYO) from the Health Demographic Surveillance System (HDSS) as a denominator, while adjusting for healthcare utilization at household level and proportion of stool specimen collected from patients who met the case definition at the surveillance hospital. Mortality rates were calculated using PYO as the denominator and number of deaths estimated using total deaths in the HDSS, proportion of deaths attributed to diarrhoea by verbal autopsy (VA) and percent positive for rotavirus AGE (RVAGE) hospitalizations. Results Of 7760 all-cause hospitalizations among children
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::738117269a4cc5d40aa0c67b06ed72c7 http://link.springer.com/article/10.1186/s12879-018-3615-6 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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