A double blind trial of the effect of cromolyn sodium on exercise-induced bronchospasm
| Autor: | Peyton A. Eggleston, Paul P. Van Arsdel, C. Warren Bierman, William E. Pierson, Stanley J. Stamm |
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| Rok vydání: | 1972 |
| Předmět: |
Adult
Male Adolescent Physical Exertion Immunology Exercise-Induced Bronchospasm Placebo Bronchospasm Double blind Cromolyn Sodium Disodium cromoglycate Humans Immunology and Allergy Medicine Child Bronchial Spasm business.industry Rhinitis Allergic Seasonal respiratory system Crossover study Asthma respiratory tract diseases Airway disease Chromones Spirometry Anesthesia Prednisone Female medicine.symptom business |
| Zdroj: | Journal of Allergy and Clinical Immunology. 50:57-63 |
| ISSN: | 0091-6749 |
| DOI: | 10.1016/0091-6749(72)90079-6 |
| Popis: | Nineteen children with atopic airway disease who had a demonstrable post-exercise decrease in forced expiratory volume in one second (FEV 1 ) using a standardized stress on a cycloergometer were treated with disodium cromoglycate (cromolyn sodium) in a double blind crossover study with a placebo control. Significant reduction of post-exercise bronchospasm was obtained by a single dose of 20 mg. of the drug inhaled one hour before exercise; the effect of the single dose was enhanced if preceded by 3 weeks of daily medication. No side effects were detected during the prolonged use of the drug. The significance of cromolyn's effect on the phenomenon is discussed. |
| Databáze: | OpenAIRE |
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