Composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) hydrogels synthesized using UV and gamma irradiation: comparison of material properties
Autor: | Đorđe Veljović, Ivica Vujčić, Željko Janićijević, Miloš Vujisić, Filip Radovanović |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Materials science
Composite number macromolecular substances ion exchange 01 natural sciences 030218 nuclear medicine & medical imaging 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Differential scanning calorimetry 0103 physical sciences Irradiation Fourier transform infrared spectroscopy Acrylic acid Radiation 010308 nuclear & particles physics technology industry and agriculture PLGA radiation-induced synthesis biochemical phenomena metabolism and nutrition gamma irradiation chemistry Chemical engineering polymerization Self-healing hydrogels Glass transition composite hydrogel |
Zdroj: | Radiation Physics and Chemistry |
Popis: | Composite hydrogels capable of controlled drug delivery via ion exchange are an interesting group of materials for the construction of implantable drug reservoirs for electrically charged drugs. In this study, we synthesized composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) (PLGA-PAA) hydrogels by sequential application of UV or gamma irradiation and traditional phase inversion. Physicochemical properties of the composite PLGA-PAA hydrogels were investigated using Fourier transform infrared spectroscopy with attenuated total reflectance (FTIR-ATR), scanning electron microscopy (SEM), and differential scanning calorimetry (DSC). We examined the ion exchange capacity (IEC) and swelling behavior of these materials to determine their potential as drug reservoirs. Composite PLGA-PAA hydrogel synthesized using UV irradiation (UV-PLGA-PAA) exhibited a porous microstructure with submicron-sized hydrogel-rich aggregates and homogeneous chemical composition. Swelling behavior and IEC of this material were highly reproducible. Composite PLGA-PAA hydrogels synthesized using gamma irradiation (G-PLGA-PAAs) had a less uniform microstructure with larger pores and micron-sized hydrogel-rich aggregates while exhibiting rather inhomogeneous chemical composition. These materials showed superior swelling properties, but a more variable IEC, compared to the material fabricated using UV irradiation. Results of DSC analysis showed a dose-dependent decrease in glass transition temperature for G-PLGA-PAAs indicating the effects of PLGA chain scission. Our findings indicate that gamma irradiation is a possible alternative to UV irradiation in the synthesis of composite PLGA-PAA hydrogels which can modify or control important material properties. However, the synthesis protocol using gamma irradiation should be further optimized to improve the IEC reproducibility. In our future research, we will investigate the in vitro release of charged drugs from synthesized composite PLGA-PAA hydrogels under physiological conditions. Supplementary data: [https://hdl.handle.net/21.15107/rcub_dais_6944] |
Databáze: | OpenAIRE |
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