Kidney function in patients with primary distal renal tubular acidosis
| Autor: | Helena Gil-Peña, Fernando Santos, Jessica María Forero-Delgadillo, Marta Alonso-Varela |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Nephrology
medicine.medical_specialty 030232 urology & nephrology Urology Renal function 030204 cardiovascular system & hematology Kidney urologic and male genital diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Distal renal tubular acidosis Internal medicine Humans Medicine In patient Child reproductive and urinary physiology Creatinine urogenital system business.industry Metabolic acidosis Acidosis Renal Tubular medicine.disease female genital diseases and pregnancy complications Nephrocalcinosis Low birth weight chemistry Pediatrics Perinatology and Child Health medicine.symptom business Glomerular Filtration Rate |
| Zdroj: | Scopus RUO. Repositorio Institucional de la Universidad de Oviedo instname |
| ISSN: | 1432-198X 0931-041X |
| DOI: | 10.1007/s00467-021-05068-x |
| Popis: | Recent reports indicate that chronic reduction of glomerular filtration rate (GFR) is common in patients with distal renal tubular acidosis (DRTA). Factors responsible for decreased GFR need clarification. We reviewed records of 25 patients with genetically confirmed DRTA included in the RenalTube database. Patients < 18 years at diagnosis and having at least one annual follow-up were selected and classified in two groups according to GFR ≥ 90 (normal GFR) or < 90 mL/min/1.73 m2 (low GFR) after median follow-up of 8.8 years. Eighteen and seven patients had normal and low GFR (X ± SEM, 121.16 ± 28.87 and 71.80 ± 10.60 mL/min/1.73 m2, respectively, p < 0.01). At diagnosis, these 2 subgroups did not differ in sex, age, underlying mutated gene, GFR, height SDS, or percentage of ultrasound nephrocalcinosis. Serum creatinine (SCr) was different but likely due to median ages of presentation being 0.6 and 4.0 in normal and low GFR patients, respectively. On the last recorded visit, no differences between both groups were found in serum bicarbonate, serum potassium, or alkali dosage. Height SDS of patients with normal GFR was − 0.15 ± 0.47 whereas it was − 1.06 ± 0.60 in the low GFR group (p = 0.27). Interestingly, 23% of the whole group had low birth weight (LBW; < 2500 g), equating to 20% and 29% in the normal and low GFR patients, respectively (p = 0.65). Our findings confirm the risk of kidney function reduction in patients with DRTA of pediatric age onset, suggesting that low GFR is related with less favorable growth outcome and discloses the high frequency of LBW in primary DRTA, a hitherto unrecognized feature. |
| Databáze: | OpenAIRE |
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