The assessment of biologic treatment in patients with rheumatoid arthritis using FDG-PET/CT
| Autor: | Tsutomu Kobayashi, Yukiko Arisaka, Noboru Oriuchi, Yoshito Tsushima, Kimihiko Takeuchi, Yukio Yonemoto, Kenji Takagishi, Koichi Okamura |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male musculoskeletal diseases medicine.medical_specialty Elbow Standardized uptake value Wrist Multimodal Imaging Severity of Illness Index Receptors Tumor Necrosis Factor Etanercept Arthritis Rheumatoid Young Adult Rheumatology Fluorodeoxyglucose F18 medicine Humans Pharmacology (medical) Aged Rank correlation Tumor Necrosis Factor-alpha business.industry Antibodies Monoclonal Middle Aged medicine.disease Infliximab Treatment Outcome medicine.anatomical_structure Antirheumatic Agents Immunoglobulin G Positron-Emission Tomography Rheumatoid arthritis Female Radiology Radiopharmaceuticals Ankle Tomography X-Ray Computed Nuclear medicine business Follow-Up Studies medicine.drug |
| Zdroj: | Rheumatology. 51:1484-1491 |
| ISSN: | 1462-0332 1462-0324 |
| DOI: | 10.1093/rheumatology/kes064 |
| Popis: | Objectives. To evaluate whether there is a correlation between the differences in joint uptake of 2-[18F]fluoro-2-deoxy-D-glucose ( 18 F-FDG) and the improvement of clinical findings in RA patients undergoing anti-TNF therapies. Methods. Twenty-two patients who received anti-TNF therapies, including infliximab for 16 patients and etanercept for 6 patients, were assessed. PET with 18 F-FDG studies and clinical assessments were performed at baseline and 6 months after the initiation of therapy. The maximal standardized uptake value (SUVmax) was used as a representative value for the assessment of the FDG uptake in the bilateral shoulder, elbow, wrist, hip, knee and ankle joints. Spearman’s rank correlation test was applied to assess the correlation between the SUV and the clinical parameters. Results. The SUV (12 joints), the difference in the SUVmax of the affected 12 joints before and after treatment, was positively correlated with the DAS28 (r = 0.609, P = 0.003), DAS28-CRP (r = 0.656, P = 0.001) and tender joint count (TJC) (r = 0.609, P = 0.003). There were also significantly positive correlations between SUV (8 joints); the difference in the SUVmax of the bilateral shoulder, elbow, wrist and knee joints before and after treatment and the DAS28 (r = 0.642, P = 0.001), DAS28-CRP (r = 0.712, P < 0.001) and TJC (r = 0.608, P = 0.003), respectively. Conclusion. The FDG uptake observed in the inflamed RA joints may reflect disease activity. The FDG-PET response was correlated with the clinical response to the biologic treatment of RA. |
| Databáze: | OpenAIRE |
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