Improving translational research in sex-specific effects of comorbidities and risk factors in ischaemic heart disease and cardioprotection: Position paper and recommendations of the ESC Working Group on Cellular Biology of the Heart
| Autor: | Hester M. den Ruijter, Péter Ferdinandy, Kirsti Ytrehus, Cinzia Perrino, Derek J. Hausenloy, Vera Regitz-Zagrosek, Rosalinda Madonna, Can Gollmann-Tepeköylü, Sabine Steffens, Elizabeth Murphy, Sophie Van Linthout, Joost P.G. Sluijter, Hans Erik Bøtker, Peter Collins, Michael S. Marber, Felix B. Engel, Sean M. Davidson, Eva Gerdts, Henrique Girão, Maurizio Pesce, Sandrine Lecour, Rainer Schulz, Bianca J.J.M. Brundel, Mariann Gyöngyösi, Linda W. van Laake |
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| Přispěvatelé: | Perrino, Cinzia, Ferdinandy, Péter, Bøtker, Hans E, Brundel, Bianca J J M, Collins, Peter, Davidson, Sean M, den Ruijter, Hester M, Engel, Felix B, Gerdts, Eva, Girao, Henrique, Gyöngyösi, Mariann, Hausenloy, Derek J, Lecour, Sandrine, Madonna, Rosalinda, Marber, Michael, Murphy, Elizabeth, Pesce, Maurizio, Regitz-Zagrosek, Vera, Sluijter, Joost P G, Steffens, Sabine, Gollmann-Tepeköylü, Can, Van Laake, Linda W, Van Linthout, Sophie, Schulz, Rainer, Ytrehus, Kirsti |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Male sex differences Physiology Psychological intervention Myocardial Ischemia Comorbidity Cardioprotection 030204 cardiovascular system & hematology Comorbidities Translational Research Biomedical 0302 clinical medicine Risk Factors OBSTRUCTIVE SLEEP-APNEA SERUM URIC-ACID comorbidities ischemia and reperfusion ischemic heart disease translational research REPERFUSION INJURY 1102 Cardiorespiratory Medicine and Haematology Cardioprotection Sex differences Ischaemic heart disease Ischaemia and reperfusion Translational research Comorbidities Cause of death Sex Characteristics Ischaemic heart disease Incidence (epidemiology) Position Paper from European Society of Cardiology Working Group POLYCYSTIC-OVARY-SYNDROME EPSILON GENE REPRESSION CARDIOVASCULAR-DISEASE CORONARY-ARTERY-DISEASE Female Cardiology and Cardiovascular Medicine Sex characteristics medicine.medical_specialty ACUTE MYOCARDIAL-INFARCTION Translational research Affect (psychology) Risk Assessment ESTROGEN-RECEPTOR-BETA 03 medical and health sciences Sex Factors Species Specificity X-CHROMOSOME INACTIVATION Physiology (medical) Sex differences medicine Animals Humans cardiovascular diseases Intensive care medicine Ischaemia and reperfusion business.industry Health Status Disparities medicine.disease Disease Models Animal 030104 developmental biology Cardiovascular System & Hematology Position paper business |
| Zdroj: | Cardiovascular Research (CVR) Perrino, C, Ferdinandy, P, Bøtker, H E, Brundel, B J J M, Collins, P, Davidson, S M, den Ruijter, H M, Engel, F B, Gerdts, E, Girao, H, Gyöngyösi, M, Hausenloy, D J, Lecour, S, Madonna, R, Marber, M, Murphy, E, Pesce, M, Regitz-Zagrosek, V, Sluijter, J P G, Steffens, S, Gollmann-Tepeköylü, C, Van Laake, L W, Van Linthout, S, Schulz, R & Ytrehus, K 2021, ' Improving translational research in sex-specific effects of comorbidities and risk factors in ischaemic heart disease and cardioprotection : position paper and recommendations of the ESC Working Group on Cellular Biology of the Hear ', Cardiovascular Research, vol. 117, no. 2, pp. 367-385 . https://doi.org/10.1093/cvr/cvaa155 Cardiovasc Res |
| Popis: | This is a pre-copyedited, author-produced version of an article accepted for publication in Cardiovascular Research (CVR) following peer review. The version of record Perrino, Ferdinandy, Bøtker, Brundel, Collins, Davidson, Den Ruijter, Engel, Gerdts, Girao, Gyöngyösi, Hausenloy, Lecour, Madonna, Marber, Murphy, Pesce, Regitz-Zagrosek, Sluijter, Steffens, Gollmann-Tepeköylü, Van Laake, Van Linthout, Schulz, Ytrehus. Improving translational research in sex-specific effects of comorbidities and risk factors in ischaemic heart disease and cardioprotection: Position paper and recommendations of the ESC Working Group on Cellular Biology of the Heart. Cardiovascular Research (CVR). 2021;117(2):367-385, is available online at: https://doi.org/10.1093/cvr/cvaa155. Ischaemic heart disease (IHD) is a complex disorder and a leading cause of death and morbidity in both men and women. Sex, however, affects several aspects of IHD, including pathophysiology, incidence, clinical presentation, diagnosis as well as treatment and outcome. Several diseases or risk factors frequently associated with IHD can modify cellular signalling cascades, thus affecting ischaemia/reperfusion injury as well as responses to cardioprotective interventions. Importantly, the prevalence and impact of risk factors and several comorbidities differ between males and females, and their effects on IHD development and prognosis might differ according to sex. The cellular and molecular mechanisms underlying these differences are still poorly understood, and their identification might have important translational implications in the prediction or prevention of risk of IHD in men and women. Despite this, most experimental studies on IHD are still undertaken in animal models in the absence of risk factors and comorbidities, and assessment of potential sex-specific differences are largely missing. This ESC WG Position Paper will discuss: (i) the importance of sex as a biological variable in cardiovascular research, (ii) major biological mechanisms underlying sex-related differences relevant to IHD risk factors and comorbidities, (iii) prospects and pitfalls of preclinical models to investigate these associations, and finally (iv) will provide recommendations to guide future research. Although gender differences also affect IHD risk in the clinical setting, they will not be discussed in detail here. |
| Databáze: | OpenAIRE |
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