Investigation of Photoprotective, Anti-Inflammatory, Antioxidant Capacities and LC–ESI–MS Phenolic Profile of Astragalus gombiformis Pomel
| Autor: | Samira Bendjedid, Hanene Djeghim, Samira Boussekine, Sabrina Lekmine, A. I. Martín-García, Chawki Bensouici, Salah Akkal, Ali Boumegoura, Kenza Kadi, Gema Nieto, Nawal Mekersi |
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| Přispěvatelé: | Ministry of Higher Education and Scientific Research (Algeria) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Ketoprofen
Health (social science) Antioxidant Astragalus gombiformis Pomel medicine.drug_class medicine.medical_treatment Cytotoxicity photoprotective effect Brine shrimp Plant Science TP1-1185 phenolic compounds LC–ESI–MS Health Professions (miscellaneous) Microbiology Anti-inflammatory Article chemistry.chemical_compound Anti-inflammatory activity medicine Food science anti-inflammatory activity Photoprotective effect biology Chemical technology antioxidative activity biology.organism_classification Quercitrin Phenolic compounds Astragalus Antioxidative activity chemistry cytotoxicity Kaempferol Food Science medicine.drug |
| Zdroj: | Foods Volume 10 Issue 8 Digital.CSIC. Repositorio Institucional del CSIC instname Foods, Vol 10, Iss 1937, p 1937 (2021) |
| ISSN: | 2304-8158 |
| DOI: | 10.3390/foods10081937 |
| Popis: | Plant-derived compounds have recently been gaining popularity as skincare factors due to their ability to absorb ultraviolet radiations and their anti-inflammatory, and antioxidant properties. In this light, this work aimed to evaluate in vitro the pharmacological activities of the butanolic extract prepared from the aerial parts of Astragalus gombiformis Pomel, an endemic species to southern Algeria. The sun protection factor was used to assess the photoprotective effect (SPF), the protein denaturation method to determine the anti-inflammatory activity, and brine shrimp nauplii and OxHLIA assay, respectively, to assess the cytotoxicity and antioxidant capacity of A. gombiformis. In addition, LC–ESI–MS analysis was employed for the characterization of the phenolic constituents of A. gombiformis. The results showed that A. gombiformis had high capacity for absorbing UV radiations with an SPF of 37.78 ± 0.85 and significant anti-inflammatory activity with a percentage inhibition of 75.38% which is close to that of diclofenac and ketoprofen. In addition, A. gombiformis was found to have effective cytotoxicity against Artemia nauplii with a DC50 value of about 44.7 µg/mL, but a weak hemolytic effect against human erythrocytes. LC–ESI–MS results detected the presence of 17 phenolic compounds with a predominance of cirsiliol, silymarin, quercitrin (quercetin-3-O-rhamnoside), and kaempferol. Taken together, these results suggest that A. gombiformis extract could be used as a skincare agent in cosmetic formulations, providing excellent antioxidant and anti-inflammatory protection, allowing the treatment of skin conditions, as well as a pharmaceutical agent with multidimensional applications. The authors are grateful to the Algerian Ministry of Higher Education and Scientific Research and the National Centre for Biotechnology Research (C.R.B.T) for their respective financial and material supports. |
| Databáze: | OpenAIRE |
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