Alcohol-mediated enhancement of postprandial lipemia: a contributing factor to an increase in plasma HDL and a decrease in risk of cardiovascular disease
| Autor: | Byung-Hong Chung, Betty E. Darnell, Ping Liang, Frank Franklin, Steve Doran, B. H. Simon Cho, Laura Osterlund, Robert A. Oster |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Risk medicine.medical_specialty food.ingredient Alcohol Drinking Lipoproteins Sterol O-acyltransferase Medicine (miscellaneous) Lecithin Phosphatidylcholine-Sterol O-Acyltransferase chemistry.chemical_compound food Internal medicine Cholesterylester transfer protein medicine Humans Lipolysis Triglycerides Glycoproteins Nutrition and Dietetics biology Cholesterol Cholesterol HDL Erythrocyte Membrane Reverse cholesterol transport Biological Transport Middle Aged Postprandial Period Cholesterol Ester Transfer Proteins Endocrinology Postprandial Liver chemistry Cardiovascular Diseases biology.protein Cholesteryl ester Female lipids (amino acids peptides and proteins) Carrier Proteins |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0002-9165 |
| DOI: | 10.1093/ajcn/78.3.391 |
| Popis: | Background Moderate alcohol consumption increases plasma HDL and lowers cardiovascular disease risk while transiently enhancing postprandial lipemia. Objective We hypothesized that the alcohol-mediated increase in postprandial triacylglycerol-rich lipoproteins (TRLs) and their clearance elevate HDL cholesterol and reverse cholesterol transport. Design We determined the effect in normolipidemic humans (n = 14) of postprandial lipemia produced 4 h after a test meal (M) or a test meal + 0.5 g alcohol/kg body wt (M+A) on postprandial changes in plasma lipids and on the balance of cholesterol between TRL and the cholesterol-rich LDL and HDL fractions (CRL) or red blood cells (RBCs) in fresh and incubated plasma or blood. Results Postprandial lipemia after the M and M+A test meals caused a 56% and 89% increase in plasma triacylglycerol, a 30% and 74% increase in TRL cholesterol, and a 3.8% and 6.6% decrease in CRL cholesterol, respectively. In vitro reaction of endogenous lecithin:cholesterol acyltransferase (EC 2.3.1.43) and cholesteryl ester transfer proteins via incubation of fasting plasma samples and postprandial M and M+A plasma samples for 16 h increased TRL cholesterol by 22.8% (0.08 mmol/L), 32.6% (0.16 mmol/L), and 45.8% (0.28 mmol/L) in plasma and by 71.1% (0.27 mmol/L), 89.4% (0.45 mmol/L), and 112.5% (0.70 mmol/L) in RBC-enriched blood, respectively. After the in vitro lipolysis of TRL, the elevation of HDL cholesterol in postprandial M+A plasma, but not in postprandial M plasma, was significantly greater than in fasting plasma. Conclusion The alcohol-mediated increase in postprandial TRL flux and the hepatic removal of postprandial TRL after the acceptance of cholesterol from CRL and cell membranes contribute to increased HDL cholesterol and enhancement of reverse cholesterol transport in humans. |
| Databáze: | OpenAIRE |
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