Lymphocytotoxic and microbial antibodies in Crohn's disease and matched controls
| Autor: | W.L. Beeken, O.E. Eade, H. Greenberg, K. Parent, A. Kapikian, B.R. MacPherson, S. Richmond, D. Gump, E. Caul, P. Mitchell |
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| Rok vydání: | 1981 |
| Předmět: |
Adult
Cytotoxicity Immunologic Male Rotavirus medicine.medical_specialty viruses Fluorescent Antibody Technique Biology medicine.disease_cause Microbiology fluids and secretions Medical microbiology Crohn Disease Reference Values Pseudomonas medicine Bacteroides Humans Lymphocytes Chlamydia Molecular Biology Aged Crohn's disease Incidence (epidemiology) General Medicine Middle Aged biology.organism_classification medicine.disease Antibodies Bacterial digestive system diseases Titer Norwalk virus Immunology biology.protein Female Antibody Chlamydia trachomatis |
| Zdroj: | Antonie van Leeuwenhoek. 47(5) |
| ISSN: | 0003-6072 |
| Popis: | Patients with Crohn's disease and age, sex and seasonally matched healthy controls were studied for cold lymphocytotoxic and a variety of microbial antibodies. Lymphocytotoxic antibody titers were increased significantly in the Crohn's patients compared to controls, but did not correlate with any of the microbial titers. Antibodies to a Pseudomonas-like bacterium and Bacteroides vulgatus were also increased in the patients, but titers to Chlamydia trachomatis, rotavirus and Norwalk virus were not elevated above control values. Analysis of microbial antibody within the patient and control groups revealed a significant (P = .001) correlation between antibodies to the Pseudomonas-like bacterium and Bacteroides vulgatus. The elevated titers to the Pseudomonas-like organisms and B. vulgatus are of potential importance, but their significance is not known at this time. There is no evidence of an increased incidence of infection with C. trachomatis, rotavirus or Norwalk virus in Crohn's disease. |
| Databáze: | OpenAIRE |
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