High frequency and long persistency of ballooning hepatocyte were associated with glucose intolerance in patients with severe obesity
Autor: | Akira Umemura, Hiroyuki Nitta, Yuji Suzuki, Yasuhiro Takikawa, Masao Nishiya, Haruka Nikai, Keisuke Kakisaka, Akira Sasaki, Tamotsu Sugai |
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Rok vydání: | 2021 |
Předmět: |
Adult
Male medicine.medical_specialty Biopsy Science Blood sugar Diseases Gastroenterology Article Body Mass Index Young Adult 03 medical and health sciences Ballooning degeneration 0302 clinical medicine Insulin resistance Non-alcoholic Fatty Liver Disease Internal medicine Glucose Intolerance medicine Humans Aged Glucose tolerance test Multidisciplinary medicine.diagnostic_test Adiponectin business.industry Area under the curve Glucose Tolerance Test Middle Aged medicine.disease Obesity Morbid Glucose Liver 030220 oncology & carcinogenesis Hepatocytes Homeostatic model assessment Medicine Female 030211 gastroenterology & hepatology Insulin Resistance business |
Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) Scientific Reports |
ISSN: | 2045-2322 |
Popis: | Nonalcoholic steatohepatitis (NASH) and glucose intolerance are associated with an increased risk of mortality in patients with severe obesity; however, whether histological findings of the liver are related to glucose intolerance in these patients remain unknown. Sixty-nine consecutive patients who underwent metabolic surgery between June 2008 and February 2020 were included; histological findings of the liver and laboratory data were analyzed. Twenty patients with biopsy-proven NASH were chronologically evaluated using sequential biopsies; data before metabolic surgery was considered as the baseline. Glucose intolerance—demonstrated by an increased area under the curve (AUC) for blood sugar (BS) during the 75-g oral glucose tolerance test—and increased homeostatic model assessment for insulin resistance (HOMA-IR) correlated with the grade of hepatocyte ballooning in patients. Patients with persistent ballooning at the follow-up biopsy had a higher HOMA-IR, high AUC for BS, and lower adiponectin level than those in patients in whom ballooning was eliminated, while there was no significant difference in body weight. We concluded that glucose intolerance was associated with the grade of hepatocyte ballooning; additionally, persistent hepatocyte ballooning sustained glucose intolerance, while elimination of hepatocyte ballooning improved the condition. Glucose intolerance may, thus, mediate balloon formation of the hepatocyte. |
Databáze: | OpenAIRE |
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