Longitudinal course of influenza C virus antibody titers of healthy adults in Sendai, Japan
Autor: | Hiroko Ito, Hidekazu Nishimura, Feng Liao, Yoko Matsuzaki, Yunhui Zhang |
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Rok vydání: | 2020 |
Předmět: |
Adult
0301 basic medicine Influenzavirus C Lineage (genetic) 030106 microbiology Antibodies Viral 03 medical and health sciences 0302 clinical medicine Japan Immunity Virology Influenza Human parasitic diseases Humans Seroprevalence 030212 general & internal medicine Child Hemagglutination assay biology Antibody titer virus diseases Hemagglutination Inhibition Tests Titer Infectious Diseases biology.protein Antibody Influenza C Virus Brazil |
Zdroj: | Journal of Clinical Virology. 133:104662 |
ISSN: | 1386-6532 |
Popis: | Background Influenza C virus causes mild respiratory diseases in humans. Previous studies suggested that the predominant hemagglutinin-esterase gene lineage circulating in children might be selected among the adult population, yet the prevalence of influenza C virus in adults has not been described. Objectives To evaluate the frequency of influenza C virus infection in adults. Study design We performed hemagglutination inhibition assays of serum samples collected at periodic occupational medical checkups from employees of a hospital. A total of 679 serum samples were collected from 57 subjects who participated in biannual medical checkups between 2011 and 2016 as part of a longitudinal series. Titers of antibodies against the C/Kanagawa and C/Sao Paulo lineage viruses were detected. Results Ten serum sample pairs from among the 57 subjects showed at least a four-fold increase in influenza C antibody titers. Samples from three subjects exhibited antibody titer increases for both the C/Kanagawa and C/Sao Paulo lineages, four subjects showed an increased titer against the C/Sao Paulo lineage, and three subjects showed an increased titer against the C/Kanagawa lineage. Half of the antibody titer increases for the C/Kanagawa lineage were detected in May 2014, while the increases for the C/Sao Paulo lineage were detected from 2011 to 2016. Conclusion The 5-year influenza C virus infection rate was estimated at 17.5 %. There were antibodies that cross-reacted with the C/Sao Paulo and C/Kanagawa lineages. The results suggest that C/Sao Paulo was the main lineage in the adult population of this area, with cocirculation of the C/Kanagawa lineage. |
Databáze: | OpenAIRE |
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