1H, 15N, 13C resonance assignment of human GAP-43
| Autor: | Andrea G. Flamm, Szymon Żerko, Nicolas Coudevylle, Anna Zawadzka-Kazimierczuk, Robert Konrat, Wiktor Koźmiński |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Vesicle fusion GAP-43 010402 general chemistry Ligands 01 natural sciences Biochemistry Actin cytoskeleton organization Article Cell membrane 03 medical and health sciences chemistry.chemical_compound GAP-43 Protein Structural Biology medicine Humans Gap-43 protein Growth cone Neurotransmitter Nuclear Magnetic Resonance Biomolecular biology Regeneration (biology) Cell Membrane Long-term potentiation 0104 chemical sciences Cell biology Neuromodulin 030104 developmental biology medicine.anatomical_structure chemistry Intrinsically disordered protein biology.protein |
| Zdroj: | Biomolecular Nmr Assignments |
| ISSN: | 1874-270X |
| Popis: | GAP-43 is a 25 kDa neuronal intrinsically disordered protein, highly abundant in the neuronal growth cone during development and regeneration. The exact molecular function(s) of GAP-43 remains unclear but it appears to be involved in growth cone guidance and actin cytoskeleton organization. Therefore, GAP-43 seems to play an important role in neurotransmitter vesicle fusion and recycling, long-term potentiation, spatial memory formation and learning. Here we report the nearly complete assignment of recombinant human GAP-43. Electronic supplementary material The online version of this article (doi:10.1007/s12104-015-9660-9) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink