Favorable effects of hydroxychloroquine on serum low density lipid in patients with systemic lupus erythematosus: A systematic review and meta-analysis
| Autor: | Xin P. Chen, Dodji Modjinou, Yosef Ayatollahi, Lakshmi K. Uppaluru, Ji W. Yoo, Loomee Doo, Catherine Kulaga, Xibei Liu, Ewa Olech, Myoung Kwan Kwak, Hamayon Babary |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Funnel plot Down-Regulation 03 medical and health sciences 0302 clinical medicine Rheumatology Prednisone Internal medicine medicine Humans Immunologic Factors Lupus Erythematosus Systemic Prospective cohort study 030203 arthritis & rheumatology business.industry Hydroxychloroquine Publication bias Middle Aged Confidence interval Lipoproteins LDL Treatment Outcome 030104 developmental biology Pooled variance Meta-analysis Female business Biomarkers medicine.drug |
| Zdroj: | International Journal of Rheumatic Diseases. 21:84-92 |
| ISSN: | 1756-1841 |
| DOI: | 10.1111/1756-185x.13159 |
| Popis: | Aims Hydroxychloroquine (HCQ) has shown to have significant immunomodulatory effects in the treatment of systemic lupus erythematosus (SLE). Current studies show favorable effects of HCQ on traditional cardiac risk factors in patients with SLE. This review examined the effects of HCQ on serum low-density lipoprotein (LDL) level in patients with SLE. Methods A systematic search of seven major literature search databases from their inception until 3 April, 2017 identified nine studies. Random-effects pooled mean difference with corresponding 95% confidence intervals (CI) were estimated. Heterogeneity was measured by I2. Publication bias was assessed by visual inspection of funnel plots. Sensitivity analysis examined whether HCQ effect on serum total cholesterol level was similar to the main analysis. The Grading of Recommendations Assessment, Development, and Evaluation system was used to assess the overall quality of evidence. Results Pooled study participants were 559 patients from eight observation studies (two before-after studies; six case-control studies) examining the effects of HCQ on serum LDL. Pooled study participants' characteristics were as follows: mean age 45.719, female 95.262%, and prednisone use 58.366%. HCQ reduced mean LDL levels by 24.397 mg/dL (95% CI 8.921–39.872; P = 0.002). The number of studies identifying statin use was too few to perform meta-regression analysis of statin use. Heterogeneity was extensive (I2 = 94.739%). Symmetrical funnel plot visualized no evidence of publication bias. Conclusion HCQ was associated with serum LDL level reduction by mean 24.397 mg/dL in patients with SLE. Future prospective studies are need to fully characterize the treatment effect. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|