Grape Seed Flour Extends Longevity by Improving Multi-Organ Dysfunction and Age-Associated Oxidative Stress and Inflammation in Healthy Rat
| Autor: | Mossadok Ben-Attia, Ezzedine Aouani, Khawla Jebari, Safwen Kadri, Michèle Veronique El May, Kamel Charradi, Ferid Limam, Mohamed Mousslim, Mohamed Mahmoudi |
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| Rok vydání: | 2021 |
| Předmět: |
Premature aging
Aging Antioxidant Multiple Organ Failure media_common.quotation_subject medicine.medical_treatment Flour Longevity Inflammation Mitochondrion Pharmacology medicine.disease_cause Antioxidants medicine Animals Vitis Rats Wistar Free-radical theory of aging media_common chemistry.chemical_classification Reactive oxygen species business.industry Polyphenols Rats Oxidative Stress chemistry Seeds Geriatrics and Gerontology medicine.symptom Reactive Oxygen Species business Oxidative stress |
| Zdroj: | The Journals of Gerontology: Series A. 77:443-451 |
| ISSN: | 1758-535X 1079-5006 |
| DOI: | 10.1093/gerona/glab259 |
| Popis: | According to the free-radical theory of aging, accumulation of reactive oxygen species (ROS) within mitochondria throughout life span leads to impairment of the main biological macromolecules as DNA, lipids, and proteins, which might be at the basis of premature aging. One way to test experimentally such a hypothesis consists in intervention studies using antioxidant nutrients aimed at limiting or inhibiting ROS production that should be able to reduce the aging rate and disease pathogenesis. Grape seed flour (GSF) contains a high level of phytochemicals among which bioactive polyphenols exhibit numerous biological properties and beneficial health effects as antioxidant, anti-inflammatory, anticarcinogenic, multi-organ (heart, liver, kidney, and brain among others) protective. The present study aimed at testing the ability of high dosing GSF (4 g/kg bw) used as a nutritional supplement to slow down aging and prolong life span of Wistar rats when administered from early life (1-month-old animals) till their natural death. Data clearly show that high-dose GSF extends organism longevity and health span by improving multi-organ damages, systemic fueling metabolism declines, and alleviated oxidative stress and inflammation in aging rats. Our data support the extending longevity effect of grape polyphenols especially when used as high dosing nutritional supplement or as natural medicine whose appropriate galenic form as solid lipid nanoformulation is currently under investigation. |
| Databáze: | OpenAIRE |
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