Structure, nitric oxide (NO) generation and antitumor activity of binuclear tetranitrosyl iron complex with 4-aminothiophenolyl as nitrosyl ferredoxins mimic
| Autor: | T. A. Kondrat’eva, Pavel V. Dorovatovskii, S. M. Aldoshin, V.N. Khrustalev, I. V. Sulimenkov, A. A. Terent’ev, A. A. Balakina, G. I. Kozub, Tatyana S. Stupina, Natalia A. Sanina, Nikolai S. Ovanesyan |
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| Rok vydání: | 2021 |
| Předmět: |
Antitumor activity
Infrared spectroscopy 010402 general chemistry 010403 inorganic & nuclear chemistry Mass spectrometry 01 natural sciences 0104 chemical sciences Nitric oxide chemistry.chemical_compound Crystallography chemistry Mössbauer spectroscopy X-ray crystallography Materials Chemistry Iron complex Physical and Theoretical Chemistry Ferredoxin |
| Zdroj: | Journal of Coordination Chemistry. 74:743-761 |
| ISSN: | 1029-0389 0095-8972 |
| Popis: | Single-crystal XRD structure of binuclear tetranitrosyliron complex [Fe2(SR)2(NO)4] (1), R = 4-aminothiophenyl, has been described. The properties of 1 were studied by IR, Mössbauer, mass spectroscopy, and amperometry. Complex 1 was shown to form long-living nitrosyl intermediates in solution, which underlies its prolonged NO donor activity. In HeLa cells, 1 caused accumulation of NF-κB p50 but decreased the levels of NF-κB p65 in the nucleus, which led to inhibition of NF-κB dependent genes. The complex also induced increase of p53 protein levels and p21 gene activity, which led to the apoptotic cell death after G2/M cell cycle phase. |
| Databáze: | OpenAIRE |
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